Histopathological changes in the liver and kidney tissues of Wistar albino rat exposed to fenitrothion

被引：41

作者：

Afshar, S. ^{[1
]}

Farshid, A. A. ^{[2
]}

Heidari, R. ^{[1
]}

Ilkhanipour, M. ^{[1
]}

机构：

[1] Urmia Univ, Fac Sci, Dept Biol, Orumiyeh, Iran

[2] Urmia Univ, Fac Vet Med, Dept Pathol, Orumiyeh, Iran

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 2008年 / 24卷 / 09期

关键词：

fenitrothion; histopathology; kidney; liver;

D O I：

10.1177/0748233708100090

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The aim of this study was to investigate the dose-related effects of fenitrothion (FNT) on the liver and kidney. The study was conducted on 8-week-old male Wistar rats that were divided into four groups (three experimental groups and one control group) and were treated orally with different doses (25, 50, 100 mg/kg) of FNT for 28 consecutive days. After treatment, the rats were anesthetized with ether and liver and kidney samples were taken for histological studies. The results showed that the histopathological changes in the liver were mainly represented by parenchymatous degeneration of hepatocytes with mild necrosis, leukocytic infiltration in the portal area, severe congestion, and hemorrhage. These changes were dose dependent. Marked tubular dilation, hydropic degeneration in tubular epithelium, moderate congestion, and hemorrhage in the cortical and medulla part of the kidney were recorded. Histopathologic examination of the liver and kidney indicated a significant injury only in rats receiving 100 mg/kg FNT. Toxicology and Industrial Health 2008; 24: 581-586.

引用

页码：581 / 586

页数：6

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