A new strategy to target regulatory T cells in solid tumors

被引：9

作者：

Thomas-Schoemann, Audrey ^{[1
,2
,3
]}

Batteux, Frederic ^{[2
]}

Alexandre, Jerome ^{[2
,4
]}

机构：

[1] Univ Paris 05, Unite Format & Rech Sci Pharmaceut & Biol, Paris, France

[2] Univ Paris 05, Fac Med, Sorbonne Paris Cite, Paris, France

[3] Hop Cochin, AP HP, Unite Fonct Pharmacocinet & Pharmacochim, F-75674 Paris, France

[4] Grp Hop Paris Ctr, AP HP, Serv Oncol, Paris, France

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 03期

关键词：

regulatory T cell; arsenic trioxide; colon cancer; oxidative stress; nitrosative stress; breast cancer; ARSENIC TRIOXIDE;

D O I：

10.4161/onci.23338

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The depletion of regulatory T cells (Tregs) is a promising therapeutic strategy to enhance antitumor immune responses. Our recent findings indicate that low doses of arsenic trioxide can delay tumor growth in murine models of colon and breast cancer by depleting Tregs through oxidative and nitrosative bursts.

引用

页数：2

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