Allosteric modulation of agonist induced G protein activation at muscarinic M4 acetylcholine receptors

被引：0
作者：
Klemt, D [1 ]
Mohr, K [1 ]
机构：
[1] Univ Bonn, Inst Pharm, D-53121 Bonn, Germany
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2004年 / 369卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
75
引用
收藏
页码：R19 / R19
页数：1
相关论文
共 50 条
  • [21] Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
    Thal, David M.
    Sun, Bingfa
    Feng, Dan
    Nawaratne, Vindhya
    Leach, Katie
    Felder, Christian C.
    Bures, Mark G.
    Evans, David A.
    Weis, William I.
    Bachhawat, Priti
    Kobilka, Tong Sun
    Sexton, Patrick M.
    Kobilka, Brian K.
    Hristopoulos, Arthur C.
    NATURE, 2016, 531 (7594) : 335 - +
  • [22] AGONIST ACTIVATION OF MUSCARINIC ACETYLCHOLINE-RECEPTORS
    HULME, EC
    CURTIS, CAM
    PAGE, KM
    JONES, PG
    CELLULAR SIGNALLING, 1993, 5 (06) : 687 - 694
  • [23] The role of the M4 lipid-sensor in the folding, trafficking, and allosteric modulation of nicotinic acetylcholine receptors
    Henault, Camille M.
    Sun, Jiayin
    Therien, J. P. Daniel
    daCosta, Corrie J. B.
    Carswell, Casey L.
    Labriola, Jonathan M.
    Juranka, Peter F.
    Baenziger, John E.
    NEUROPHARMACOLOGY, 2015, 96 : 157 - 168
  • [24] Interaction studies of multiple binding sites on M4 muscarinic acetylcholine receptors
    Lanzafame, Alfred A.
    Sexton, Patrick M.
    Christopoulos, Arthur
    MOLECULAR PHARMACOLOGY, 2006, 70 (02) : 736 - 746
  • [25] Effect of G protein-coupled receptor kinase 2 on the sensitivity of M4 muscarinic acetylcholine receptors to agonist-induced internalization and desensitization in NG108-15 cells
    Holroyd, EW
    Szekeres, PG
    Whittaker, RD
    Kelly, E
    Edwardson, JM
    JOURNAL OF NEUROCHEMISTRY, 1999, 73 (03) : 1236 - 1245
  • [26] m4 Muscarinic receptors of the cornea
    Grueb, M.
    Mielke, J.
    Rohrbach, J. M.
    OPHTHALMOLOGE, 2011, 108 (07): : 651 - 657
  • [27] Synthesis and Structure-Activity Relationships of Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor
    Kennedy, J. Phillip
    Bridges, Thomas M.
    Gentry, Patrick R.
    Brogan, John T.
    Kane, Alexander S.
    Jones, Carrie K.
    Brady, Ashley E.
    Shirey, Jana K.
    Conn, P. Jeffrey
    Lindsley, Craig W.
    CHEMMEDCHEM, 2009, 4 (10) : 1600 - 1607
  • [28] Impact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor
    Suratman, S.
    Leach, K.
    Sexton, P. M.
    Felder, C. C.
    Loiacono, R. E.
    Christopoulos, A.
    BRITISH JOURNAL OF PHARMACOLOGY, 2011, 162 (07) : 1659 - 1670
  • [29] Activation of muscarinic acetylcholine receptors via their allosteric binding sites
    Jakubik, J
    Bacakova, L
    Lisa, V
    ElFakahany, EE
    Tucek, S
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) : 8705 - 8709
  • [30] The internalization of the M2 and M4 muscarinic acetylcholine receptors involves distinct subsets of small G-proteins
    Reiner, Cindy
    Nathanson, Neil M.
    LIFE SCIENCES, 2008, 82 (13-14) : 718 - 727
12345