Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis

被引：34

作者：

Dogra, Surbhi ^{[1
]}

Kar, Aditya K. ^{[2
]}

Girdhar, Khyati ^{[1
]}

Daniel, P. Vineeth ^{[1
]}

Chatterjee, Swarup ^{[1
]}

Choubey, Abhinav ^{[1
]}

Ghosh, Subrata ^{[1
]}

Patnaik, Satyakam ^{[2
]}

Ghosh, Debabrata ^{[2
]}

Mondal, Prosenjit ^{[1
]}

机构：

[1] Indian Inst Technol Mandi, Sch Basic Sci, Mandi, Himachal Prades, India

[2] ITTR, CSIR, Lucknow, Uttar Pradesh, India

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2019年 / 17卷

关键词：

AMPK; LKB1; Non alcoholic fatty liver disease; SREBP1c; SIRT1; ZnO NP; INSULIN-RESISTANCE; LIPID-METABOLISM; LIVER; SREBP-1C; LIPOGENESIS; PATHOGENESIS; EXPRESSION; METFORMIN; PROMOTER; PATHWAY;

D O I：

10.1016/j.nano.2019.01.013

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Insulin resistance is thought to be a common link between obesity and Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD has now reached epidemic status worldwide and identification of molecules or pathways as newer therapeutic strategies either to prevent or overcome insulin resistance seems critical. Dysregulated hepatic lipogenesis (DNL) is a hallmark of NAFLD in humans and rodents. Therefore, reducing DNL accretion may be critical in the development of therapeutics of NAFLD. In our in vivo model (high-fat-diet fed [HFD] obese mice) we found Zinc oxide nanoparticles (ZnO NPs) significantly decreased HFD-induced hepatic steatosis and peripheral insulin resistance. This protective mechanism of ZnO NPs was signaled through hepatic SIRT1-LKB1-AMPK which restricted SREBP-lc within the cytosol limiting its transcriptional ability and thereby ameliorating HFD mediated DNL. These observations indicate that ZnO NP can serve as a therapeutic strategy to improve the physiological homeostasis during obesity and its associated metabolic abnormalities. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：210 / 222

页数：13

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