Covalent analogues of DNA base-pairs and triplets. Part 2. Synthesis and cytostatic activity of bis(purin-6-yl) acetylenes, -diacetylenes and related compounds

被引：34

作者：

Hocek, M ^{[1
]}

Votruba, I ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CZ-16610 Prague 6, Czech Republic

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(02)00077-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The title bis(purin-6-yl)acetylenes, -diacetylenes, -ethylenes and -ethanes were prepared as covalent base-pair analogues starting from 6-ethynylpurines and 6-iodopurines by cross-coupling and homo-coupling reactions and hydrogenations. The bis(purin-6-yl)acetylenes and -diacetylenes exhibited significant cytostatic activity in vitro (IC50=0.4-1.0 mumol/l). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1055 / 1058

页数：4

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