Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?

被引：110

作者：

Buscher, Philippe ^{[1
]}

Bart, Jean-Mathieu ^{[2
,3
]}

Boelaert, Marleen ^{[4
]}

Bucheton, Bruno ^{[2
]}

Cecchi, Giuliano ^{[5
]}

Chitnis, Nakul ^{[6
,7
]}

Courtin, David ^{[8
]}

Figueiredo, Luisa M. ^{[9
]}

Franco, Jose-Ramon ^{[10
]}

Grebaut, Pascal ^{[2
]}

Hasker, Epco ^{[4
]}

Ilboudo, Hamidou ^{[11
]}

Jamonneau, Vincent ^{[2
]}

Koffi, Mathurin ^{[12
]}

Lejon, Veerle ^{[2
]}

MacLeod, Annette ^{[13
]}

Masumu, Justin ^{[14
]}

Matovu, Enock ^{[15
]}

Mattioli, Raffaele ^{[16
]}

Noyes, Harry ^{[17
]}

Picado, Albert ^{[18
]}

Rock, Kat S. ^{[19
]}

Rotureau, Brice ^{[20
,21
]}

Simo, Gustave ^{[22
]}

Thevenon, Sophie ^{[2
,23
]}

Trindade, Sandra ^{[9
]}

Truc, Philippe ^{[2
]}

Van Reet, Nick ^{[1
]}

机构：

[1] Inst Trop Med, Dept Biomed Sci, Natl Str 155, B-2000 Antwerp, Belgium

[2] Univ Montpellier, INTERTRYP, IRD, CIRAD, Montpellier, France

[3] Inst Salud Carlos III, Ctr Nacl Med Trop, Calle Sinesio Delgado 4, Madrid 28029, Spain

[4] Inst Trop Med, Dept Publ Hlth, Natl Str 155, B-2000 Antwerp, Belgium

[5] Food & Agr Org United Nation, Subreg Off Eastern Afr, CMC Rd,Kebele 12-13,POB 5536, Addis Ababa, Ethiopia

[6] Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Socinstr 57, CH-4002 Basel, Switzerland

[7] Univ Basel, Basel, Switzerland

[8] Univ Paris 05, Inst Rech Dev, Unite MERIT, Mere & Enfant Face Infect Trop, 4 Ave Observ, F-75006 Paris, France

[9] Univ Lisbon, Inst Med Mol, Fac Med, Ave Prof Egas Moniz, P-1649028 Lisbon, Portugal

[10] WHO, Control Neglected Trop Dis Innovat & Intensifie D, Via Appia 20, CH-1202 Geneva, Switzerland

[11] Inst Rech Bases Biol Lutte Integree, Ctr Int Rech Dev Elevage Zone Subhumide, 01 BP 454, Bobo Dioulasso 01, Burkina Faso

[12] Univ Jean Lorougnon Guede, BP 150, Daloa, Cote Ivoire

[13] Univ Glasgow, Inst Biodivers Anim Hlth & Comparat Med, Henry Wellcome Bldg,464 Bearsden Rd, Glasgow, Lanark, Scotland

[14] Inst Natl Rech Biomed, Dept Parasitol, Ave Democratie,BP 1197, Kinshasa 1, DEM REP CONGO

[15] Makerere Univ, Coll Vet Med, Anim Resources & Biosecur, POB 7062, Kampala, Uganda

[16] Food & Agr Org United Nat, Anim Prod & Hlth Div, Viale Terme Caracalla, I-00153 Rome, Italy

[17] Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England

[18] Fdn Innovat New Diagnost, 9 Chemin Mines, CH-1202 Geneva, Switzerland

[19] Univ Warwick, Zeeman Inst Syst Biol & Infect Dis Res, Gibbet Hill Rd, Coventry CV4 7AL, W Midlands, England

[20] Inst Pasteur, Trypanosome Transmiss Grp, Trypanosome Cell Biol Unit, INSERM U1201, 25 Rue Dr Roux, F-75015 Paris, France

[21] Inst Pasteur, Dept Parasites & Insect Vectors, 25 Rue Dr Roux, F-75015 Paris, France

[22] Univ Dschang, Dept Chem, Fac Sci, POB 67, Dschang, Cameroon

[23] CIRAD, INTERTRYP, Montpellier, France

来源：

TRENDS IN PARASITOLOGY | 2018年 / 34卷 / 03期

基金：

比尔及梅琳达.盖茨基金会; 英国惠康基金;

关键词：

TRYPANOSOMA-BRUCEI-GAMBIENSE; HUMAN AFRICAN TRYPANOSOMIASIS; INCUBATION INFECTIVITY TEST; ANIMAL RESERVOIR; TRYPANOZOON; TSETSE; IDENTIFICATION; PIGS; TRANSMISSION; MODELS;

D O I：

10.1016/j.pt.2017.11.008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between 1990 and 2015, almost 440 000 cases were reported. Large-scale screening of populations at risk, drug donations, and efforts by national and international stakeholders have brought the epidemic under control with <2200 cases in 2016. The World Health Organization (WHO) has set the goals of gambiense-HAT elimination as a public health problem for 2020, and of interruption of transmission to humans for 2030. Latent human infections and possible animal reservoirs may challenge these goals. It remains largely unknown whether, and to what extend, they have an impact on gambiense-HAT transmission. We argue that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.

引用

页码：197 / 207

页数：11

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