Recent Developments in Texaphyrin Chemistry and Drug Discovery

被引：64

作者：

Preihs, Christian ^{[1
]}

Arambula, Jonathan F. ^{[1
,4
]}

Magda, Darren ^{[2
]}

Jeong, Heeyeong ^{[3
]}

Yoo, Dongwon ^{[3
]}

Cheon, Jinwoo ^{[3
]}

Siddik, Zahid H. ^{[4
]}

Sessler, Jonathan L. ^{[1
,3
]}

机构：

[1] Univ Texas Austin, Dept Chem & Biochem, Austin, TX 78712 USA

[2] Lumiphore Inc, Richmond, CA 94804 USA

[3] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

[4] UT MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

来源：

INORGANIC CHEMISTRY | 2013年 / 52卷 / 21期

基金：

新加坡国家研究基金会;

关键词：

MOTEXAFIN GADOLINIUM; PHOTODYNAMIC THERAPY; EXPANDED PORPHYRINS; MONOCLONAL-ANTIBODY; BRAIN METASTASES; METAL-COMPLEXES; CISPLATIN; RADIATION; P53; CANCER;

D O I：

10.1021/ic400226g

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Texaphyrins are pentaaza expanded porphyrins with the ability to form stable complexes with a variety of metal cations, particularly those of the lanthanide series. In biological milieus, texaphyrins act as redox mediators and mediate the production of reactive oxygen species (ROS). In this review, newer studies involving texaphyrin complexes targeting several different applications in anticancer therapy are described. In particular, the preparation of bismuth and lead texaphyrin complexes as potential alpha-core emitters for radiotherapy is detailed, as are gadolinium texaphyrin functionalized magnetic nanoparticles with features that make them of interest as dual-mode magnetic resonance imaging contrast agents and as constructs with anticancer activity mediated through ROS-induced sensitization and concurrent hyperthermia. Also discussed are gadolinium texaphyrin complexes as possible carrier systems for the targeted delivery of platinum payloads.

引用

页码：12184 / 12192

页数：9

共 69 条

[51] AN EXPANDED PORPHYRIN - THE SYNTHESIS AND STRUCTURE OF A NEW AROMATIC PENTADENTATE LIGAND [J].

SESSLER, JL ;

MURAI, T ;

LYNCH, V ;

CYR, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (16) :5586-5588

[52] Pulse radiolytic studies of metallotexaphyrins in the presence of oxygen:: Relevance of the equilibrium with superoxide anion to the mechanism of action of the radiation sensitizer motexafin gadolinium (Gd-Tex2+, Xcytrin) [J].

Sessler, JL ;

Tvermoes, NA ;

Guldi, DM ;

Hug, GL ;

Mody, TD ;

Magda, D .

JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (07) :1452-1457

[53] Biomedical applications of lanthanide(III) texaphyrins lutetium(III) texaphyrins as potential photodynamic therapy photosensitizers [J].

Sessler, JL ;

Dow, WC ;

OConnor, D ;

Harriman, A ;

Hemmi, G ;

Mody, TD ;

Miller, RA ;

Qing, F ;

Springs, S ;

Woodburn, K ;

Young, SW .

JOURNAL OF ALLOYS AND COMPOUNDS, 1997, 249 (1-2) :146-152

[54] Texaphyrins - New drugs with diverse clinical applications in radiation and photodynamic therapy [J].

Sessler, JL ;

Miller, RA .

BIOCHEMICAL PHARMACOLOGY, 2000, 59 (07) :733-739

[55] BINDING OF PYRIDINE AND BENZIMIDAZOLE TO A CADMIUM EXPANDED PORPHYRIN - SOLUTION AND X-RAY STRUCTURAL STUDIES [J].

SESSLER, JL ;

MURAI, T ;

LYNCH, V .

INORGANIC CHEMISTRY, 1989, 28 (07) :1333-1341

[56] One-electron reduction and oxidation studies of the radiation sensitizer gadolinium(III) texaphyrin (PCI-0120) and other water soluble metallotexaphyrins [J].

Sessler, JL ;

Tvermoes, NA ;

Guldi, DM ;

Mody, TD ;

Allen, WE .

JOURNAL OF PHYSICAL CHEMISTRY A, 1999, 103 (07) :787-794

[57] SYNTHESIS AND CRYSTAL-STRUCTURE OF A NOVEL TRIPYRRANE-CONTAINING PORPHYRINOGEN-LIKE MACROCYCLE [J].

SESSLER, JL ;

JOHNSON, MR ;

LYNCH, V .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (19) :4394-4397

[58]

SESSLER JL, 1992, NEW J CHEM, V16, P541

[59] SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF LANTHANIDE(III) TEXAPHYRINS [J].

SESSLER, JL ;

MODY, TD ;

HEMMI, GW ;

LYNCH, V .

INORGANIC CHEMISTRY, 1993, 32 (14) :3175-3187

[60] EXPANDED PORPHYRINS - THE SYNTHESIS AND METAL-BINDING PROPERTIES OF NOVEL TRIPYRRANE-CONTAINING MACROCYCLES [J].

SESSLER, JL ;

JOHNSON, MR ;

LYNCH, V ;

MURAI, T .

JOURNAL OF COORDINATION CHEMISTRY, 1988, 18 (1-3) :99-104

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