Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis

被引：167

作者：

Cao, Yihai ^{[1
,2
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden

[2] Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden

来源：

TRENDS IN MOLECULAR MEDICINE | 2013年 / 19卷 / 08期

基金：

瑞典研究理事会; 欧洲研究理事会;

关键词：

PDGF; tumor growth; metastasis; tumor microenvironment; targeted therapy; CANCER-ASSOCIATED FIBROBLASTS; EPITHELIAL-MESENCHYMAL TRANSITION; PROTEASE-ACTIVATED LIGAND; FACTOR-BETA RECEPTOR; TGF-BETA; ENDOTHELIAL-CELLS; ALPHA-RECEPTOR; AUTOCRINE STIMULATION; TYROSINE KINASE; FACTOR-B;

D O I：

10.1016/j.molmed.2013.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are frequently expressed in various tumors and their expression levels correlate with tumor growth, invasiveness, drug resistance, and poor clinical outcomes. Emerging experimental evidence demonstrates that PDGFs exhibit multiple functions in modulation of tumor growth, metastasis, and the tumor microenvironment by targeting malignant cells, vascular cells, and stromal cells. Understanding PDGF PDGFR-mediated molecular signaling may provide new mechanistic rationales for optimizing current cancer therapies and the development of future novel therapeutic modalities.

引用

页码：460 / 473

页数：14

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