Separating closely resembling steroids with ionic liquids in liquid-liquid extraction systems

被引：12
作者：
Vitasari, Caecilia R. [1 ]
Gramblicka, Michal [2 ]
Gibcus, Kristel [3 ]
Visser, Ton J. [3 ]
Geertman, Rob [4 ]
Schuur, Boelo [2 ]
机构：
[1] Inst Sustainable Proc Technol, NL-3818 JN Amersfoort, Netherlands
[2] Univ Twente, Sustainable Proc Technol Grp, Fac Sci & Technol, NL-7500 AE Enschede, Netherlands
[3] Syncom BV, NL-9747 AT Groningen, Netherlands
[4] DSM Fibre Intermediates BV, NL-6167 RD Geleen, Netherlands
来源：
SEPARATION AND PURIFICATION TECHNOLOGY | 2015年 / 155卷
关键词：
Liquid-liquid extraction; Ionic liquids; Steroids; Pregnenolone; Progesterone; SOLVENT-IMPREGNATED RESINS; MOVING-BED CHROMATOGRAPHY; MEMBRANES SMILMS; REMOVAL; WATER; PHENOL;
D O I：
10.1016/j.seppur.2015.04.002
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Separation of steroids by liquid-liquid extraction with ionic liquids (ILs) as solvent was studied both experimentally and by simulation using a model mixture of progesterone and pregnenolone. The studies involved a solvent screening using COSMO-RS software for estimation of progesterone solubility. An experimental compatibility study of several solvents with reasonable progesterone solubility with several ILs. The results showed tert-butyl methyl ether (TBME)-butyl methyl imidazolium tetrafluoroborate (BMIM BE4) as the most promising solvent combination. Next, equilibrium partitioning of both progesterone and pregnenolone in this solvent combination was determined experimentally. Fixed bed studies using solvent impregnated resin (SIR) obtained by impregnation of BMIM BF4 in silica showed that it is feasible to obtain highly pure progesterone in such a process. However, the yield was far from quantitative and thus a fractional extraction process was studied by simulation of a counter current extraction process. The simulation study showed that with fractional extraction highly pure progesterone (excess >0.99) can be obtained at a yield of >0.95 when a minimum of 24 equilibrium stages are applied. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：58 / 65
页数：8
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