Amberlite IR-120(H)-mediated "on water" synthesis of novel anticancer ruthenium(II)-p-cymene 2-pyridinylbenzothiazole (BTZ), 2-pyridinylbenzoxazole (BOZ) & 2-pyridinylbenzimidazole (BIZ) scaffolds

被引：26

作者：

Subran, Sunisha Kottukulam ^{[1
]}

Banerjee, Swagata ^{[1
]}

Mondal, Ashaparna ^{[1
]}

Paira, Priyankar ^{[1
]}

机构：

[1] VIT Univ, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India

来源：

NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 12期

关键词：

BENZOTHIAZOLE DERIVATIVES; RUTHENIUM COMPLEXES; ARENE COMPLEXES; INHIBITORS; DESIGN; 2-ARYLBENZOTHIAZOLE; BENZIMIDAZOLE; EFFICIENT; ANALOGS; CANCER;

D O I：

10.1039/c6nj02049f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we have introduced a novel, green and effective methodology for the synthesis of Ru(II) arene 2-pyridinylbenzothiazole, Ru(II) arene 2-pyridinylbenzoxazole & Ru(II) arene 2-pyridinylbenzimidazole complexes in a one-pot sequence. A convenient and clean "on water" synthesis of organoruthenium is reported. Amberlite IR-120(H) has been employed as a reusable catalyst in this reaction. The operational simplicity, excellent yield, ease of product isolation and high chemoselectivity are the main advantages of this method; moreover, this process is economical, safe and environmentally benign. This method offers the opportunity of synthesizing a variety of newer organoruthenium scaffolds for anticancer screening. Most of the compounds presented here have displayed significant cytotoxicity & selectivity against MCF7, Hela and A2780 cell lines compared to cisplatin. Since, [(eta(6)-p-cymene)Ru-2-(6-bromopyridin-2-yl)benzo[d]thiazole] (4g) was identified as the most potent fluorescent scaffold in terms of cytotoxicity & selectivity in the cancer cell tines, it might be used in cancer theranostics.

引用

页码：10333 / 10343

页数：11

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