Dexmedetomidine preserves attention/calculation when used for cooperative and short-term intensive care unit sedation

被引:25
|
作者
Goodwin, Haley E. [1 ,2 ]
Gill, Randeep S. [3 ]
Murakami, Peter N. [4 ]
Thompson, Carol B. [4 ]
Lewin, John J., III [1 ,2 ,5 ]
Mirski, Marek A. [5 ]
机构
[1] Johns Hopkins Univ Hosp, Dept Pharm, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ Hosp, Dept Anesthesiol, Baltimore, MD 21287 USA
[3] Columbia Univ Coll Phys & Surg, Dept Neurol & Neurocrit Care, New York, NY 10032 USA
[4] Johns Hopkins Bloomberg Sch Publ Hlth, Johns Hopkins Biostat Ctr, Baltimore, MD USA
[5] Johns Hopkins Med, Dept Crit Care Med, Baltimore, MD USA
关键词
Critical care; Sedatives; Cognition; Dexmedetomidine; Propofol; Delirium; CRITICALLY-ILL PATIENTS; TRIAL; RELIABILITY; VALIDITY;
D O I
10.1016/j.jcrc.2013.07.062
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Purpose: Differential effects on cognition were recently demonstrated between dexmedetomidine (DEX) and propofol (PRO) when used for cooperative sedation. Propofol was found to reduce cognition, whereas DEX improved cognition. To further discriminate these effects, we evaluated the effect of PRO vs DEX in selected areas of cognition. Methods: This is a post hoc analysis of the Acute Neurologic Intensive Care Unit Sedation Trial and an investigator-initiated, prospective, randomized, double-blinded, crossover study, comparing the effect of PRO and DEX on cognition measure by the Johns Hopkins Adapted Cognitive Exam (ACE). A linear model analysis accounting for within-patient correlation of measures was used to estimate differences in ACE subscales between drugs. Results: Propofol diminished adjusted scores on all ACE subscales (P<.05), whereas DEX improved adjusted scores selectively for attention/calculation (3.55; 95% confidence interval, 1.49-5.61; P<.01). The positive and significant difference in ACE scores between agents was present across subscales. Conclusions: Our findings indicate that DEX improved ACE attention/calculation subscale in awake patients receiving cooperative sedation. This is in contrast to the deterioration in all mean ACE subscale scores observed using PRO, suggesting DEX preserved cognitive function with specific preservation of focus and attention and allows for greater cognition compared with PRO across all cognitive domains. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:1113.e7 / 1113.e10
页数:4
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