Contact-free inactivation of Trichophyton rubrum and Microsporum canis by cold atmospheric plasma treatment

被引：40

作者：

Heinlin, Julia ^{[1
]}

Maisch, Tim ^{[1
]}

Zimmermann, Julia L. ^{[2
]}

Shimizu, Tetsuji ^{[2
]}

Holzmann, Thomas ^{[3
]}

Simon, Michaela

Heider, Judith ^{[1
]}

Landthaler, Michael ^{[1
]}

Morfill, Gregor ^{[2
]}

Karrer, Sigrid ^{[1
]}

机构：

[1] Univ Hosp Regensburg, Dept Dermatol, Regensburg, Germany

[2] Max Planck Inst Extraterr Phys, D-85748 Garching, Germany

[3] Univ Hosp Regensburg, Dept Med Microbiol & Hyg, Regensburg, Germany

来源：

FUTURE MICROBIOLOGY | 2013年 / 8卷 / 09期

关键词：

CAP; cold atmospheric plasmas; dermatophytes; disinfection; plasma medicine; CHRONIC WOUNDS; ARGON PLASMA; STERILIZATION; OXYGEN; AIR; BIOFILMS; SPORES;

D O I：

10.2217/fmb.13.86

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: Cold atmospheric plasma (CAP) has already proven efficient at disinfection of microorganisms including biofilms. The objective of the present study is to assess the efficacy of CAP against the dermatophytes Trichophyton rubrum and Microsporum canis in vitro. Materials & methods:T. rubrum and M. canis were exposed to CAP for different treatment times and time intervals in vitro. Treatment with ciclopirox olamine or UVC radiation (0.120 J/cm(2)) served as controls. CAP was generated by the surface microdischarge technology. Fungal colony growth was measured upon CAP treatment. Results: Repeated daily CAP treatments of 10 min demonstrated an inhibition of growth during the treatment period of 9 days. Single CAP treatment sessions for 5, 8 and 10 min, as well as treatments for 5 or 8 min daily, resulted in less fungal growth inhibition. UVC radiation treatment failed, but not ciclopirox olamine. Conclusion: CAP shows promising potential for future application in the treatment of dermatophyte infections.

引用

页码：1097 / 1106

页数：10

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