TLN-4601 inhibits Ras-MAPK signaling upstream of MEK

被引:0
|
作者
Boufaied, Nadia [1 ]
Falardeau, Pierre [1 ]
Gourdeau, Henriette [1 ]
机构
[1] Thall Pharmaceut, Montreal, PQ, Canada
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4374
引用
收藏
页数:2
相关论文
共 50 条
  • [1] TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation
    Boufaied, Nadia
    Wioland, My-Anh
    Falardeau, Pierre
    Gourdeau, Henriette
    ANTI-CANCER DRUGS, 2010, 21 (05) : 543 - 552
  • [2] A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression
    Mason, Warren P.
    Belanger, Karl
    Nicholas, Garth
    Vallieres, Isabelle
    Mathieu, David
    Kavan, Petr
    Desjardins, Annick
    Omuro, Antonio
    Reymond, Didier
    JOURNAL OF NEURO-ONCOLOGY, 2012, 107 (02) : 343 - 349
  • [3] A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression
    Warren P. Mason
    Karl Belanger
    Garth Nicholas
    Isabelle Vallières
    David Mathieu
    Petr Kavan
    Annick Desjardins
    Antonio Omuro
    Didier Reymond
    Journal of Neuro-Oncology, 2012, 107 : 343 - 349
  • [4] TLN-4601, a K-Ras signaling inhibitor, sensitizes to TK inhibitors in resistant cells with activating K-Ras mutations
    Haidara, Khadidja
    Gourdeau, Henriette
    Thibaudeau, Eric
    Boufaied, Ines
    Falardeau, Pierre
    Cohen, Victor
    Batist, Gerald
    CANCER RESEARCH, 2009, 69
  • [5] Focus on targeting the Ras-MAPK pathway: the Mek inhibitors
    Baldini, Capucine
    Duchemann, Boris
    Hollebecque, Antoine
    Routier, Emilie
    Varga, Andreea
    Gazzah, Anas
    Bahleda, Rastio
    Besse, Benjamin
    Soria, Jean-Charles
    Massard, Christophe
    BULLETIN DU CANCER, 2012, 99 (09) : 865 - 874
  • [6] Hydralazine inhibits T cell DNA methylation by inhibiing ras-MAPK signaling.
    Deng, C
    Rao, T
    Richardson, BC
    ARTHRITIS AND RHEUMATISM, 1999, 42 (09): : S101 - S101
  • [7] Hydralazine inhibits T cell DNA methylation by inhibiting ras-MAPK signaling.
    Deng, C
    Zhang, A
    Rao, T
    Richardson, B
    JOURNAL OF INVESTIGATIVE MEDICINE, 2000, 48 (05) : 262A - 262A
  • [8] FRZB is induced by RAS-MAPK signaling and counteracts transformation
    Onoyama, Ichiro
    Kato, Masaya
    Kodama, Keisuke
    Yagi, Hiroshi
    Asanoma, Kazuo
    Sonoda, Kenzo
    Kato, Kiyoko
    CANCER SCIENCE, 2018, 109 : 750 - 750
  • [9] Ras-MAPK signaling in osteogenic differentiation: Friend or foe?
    Schindeler, Aaron
    Little, David G.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 (09) : 1331 - 1338
  • [10] Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition
    Kapp, Friedrich G.
    Bazgir, Farhad
    Mahammadzade, Nagi
    Mehrabipour, Mehrnaz
    Vassella, Erik
    Bernhard, Sarah M.
    Doering, Yvonne
    Holm, Annegret
    Karow, Axel
    Seebauer, Caroline
    da Silva, Natascha Platz Batista
    Wohlgemuth, Walter A.
    Oppenheimer, Aviv
    Kroening, Pia
    Niemeyer, Charlotte M.
    Schanze, Denny
    Zenker, Martin
    Eng, Whitney
    Ahmadian, Mohammad R.
    Baumgartner, Iris
    Roessler, Jochen
    ANGIOGENESIS, 2024, 27 (04) : 739 - 752