Gut-Brain Axis: Potential Factors Involved in the Pathogenesis of Parkinson's Disease

被引:21
作者
Chao, Yin-Xia [1 ,2 ,3 ]
Gulam, Muhammad Yaaseen [1 ]
Chia, Nicholas Shyh Jenn [1 ]
Feng, Lei [4 ]
Rotzschke, Olaf [5 ]
Tan, Eng-King [1 ,2 ,3 ]
机构
[1] Natl Neurosci Inst, Dept Neurol, Singapore, Singapore
[2] Singapore Gen Hosp, Dept Neurol, Singapore, Singapore
[3] Duke NUS Med Sch, Singapore, Singapore
[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore
[5] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore, Singapore
来源
FRONTIERS IN NEUROLOGY | 2020年 / 11卷
基金
英国医学研究理事会;
关键词
Parkinson's disease (PD); gut; genetics; microbiome; diet; HELICOBACTER-PYLORI; ALPHA-SYNUCLEIN; RISK-FACTORS; SYMPTOMS; CONSTIPATION; EPIDEMIOLOGY; ASSOCIATION; MICROBIOTA; NUMBER; CELLS;
D O I
10.3389/fneur.2020.00849
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Increasing evidence suggests an association between gastrointestinal (GI) disorders and susceptibility and progress of Parkinson's disease (PD). Gut-brain axis has been proposed to play important roles in the pathogenesis of PD, though the exact pathophysiologic mechanism has yet to be elucidated. Here, we discuss the common factors involved in both PD and GI disorders, including genes, altered gut microbiota, diet, environmental toxins, and altered mucosal immunity. Large-scale prospective clinical studies are needed to define the exact relationship between dietary factors, microbiome, and genetic factors in PD. Identification of early diagnostic markers and demonstration of the efficacy of diet modulation and regulation of gut microbiome through specific therapeutics can potentially change the treatment paradigm for PD.
引用
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页数:6
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