Synthesis, characterization and antimicrobial activity of novel platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N′-di-3-propanoic acid - Crystal structure of H2-1,2-dpheddp•2HCl•H2O

被引：8

作者：

Radic, Gordana P. ^{[1
]}

Glodovic, Verica V. ^{[1
]}

Ratkovic, Zoran R. ^{[1
]}

Novakovic, Sladana B. ^{[2
]}

Garcia-Granda, Santiago ^{[3
]}

Roces, Laura ^{[3
]}

Menendez-Taboada, Laura ^{[3
]}

Radojevic, Ivana D. ^{[4
]}

Stefanovic, Olgica D. ^{[4
]}

Comic, Ljiljana R. ^{[4
]}

Trifunovic, Srecko R. ^{[1
]}

机构：

[1] Univ Kragujevac, Dept Chem, Fac Sci, Kragujevac 34000, Serbia

[2] Univ Belgrade, VINCA Inst Nucl Sci, Lab Theoret Phys & Condensed Matter Phys, Belgrade 11001, Serbia

[3] Univ Oviedo, Phys & Analyt Chem Dept, E-33006 Oviedo, Spain

[4] Univ Kragujevac, Dept Biol & Ecol, Fac Sci, Kragujevac 34000, Serbia

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2012年 / 1029卷

关键词：

Meso-1,2-diphenyl-ethylenediamine-N,N '-di-3-propanoic acid; Platinum(IV) complex; Palladium(II) complex; Infrared spectroscopy; Crystal structure; Antimicrobial activity; COBALT(III) COMPLEXES; MERIDIONAL ISOMERS; RHODIUM(III) COMPLEXES; CIRCULAR-DICHROISM; ANTITUMOR-ACTIVITY; EDTA-TYPE; ANTIBACTERIAL; LIGANDS; COORDINATION; ANTIFUNGAL;

D O I：

10.1016/j.molstruc.2012.07.007

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In the reaction of meso-1,2-diphenyl-ethylenediamine (1,2-dphen) with neutralized 3-chlor-propanoic acid, the new linear tetradentate edda-like ligand (edda = ethylenediamine-N,N'-diacetic ion) meso-1, 2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid dihydrochloride monohydrate (H-2-1,2-dpheddp center dot 2HCl center dot H2O) was prepared. The corresponding platinum(IV) complex, s-cis-dichlorido-(meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoate)-platinum(IV) ([PtCl2(1,2-dpheddp)]) was synthesized by heating potassium-hexachloridoplatinate(IV) and H-2-1,2-dpheddp center dot 2HCl center dot H2O on steam bath for 12 h with neutralization by means of lithium-hydroxide. The palladium(II) complex, cis-dichlorido-(meso-1,2diphenyl-ethylenediamine-N,N'-di-3-propanoate)-palladium(II) (IPdCl2(1,2-dpheddp)]) was obtained in the similar way using potassium-tetrachloridopalladate(II), H-2-1,2-dpheddp-2HCl center dot H2O and lithium-hydroxide. The compounds were characterized by elemental analysis and infrared spectroscopy. The spectroscopically predicted structure of the synthesized tetradentate ligand was confirmed by X-ray analysis of the H-2-1,2-dpheddp.2HCl center dot H2O. Antimicrobial activity of the ligand and corresponding palladium(II) and platinum(IV) complexes is investigated against 25 species of microorganisms. Testing is preformed by microdilution method and minimum inhibitory concentrations (MIC) and minimum microbicidal concentration (MMC) have been determined. The difference between antimicrobial activity of the ligand and corresponding platinum(IV) and palladium(II) complex is noticed and, in general, palladium(II) complex was the most active. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：180 / 186

页数：7