The association of ACE, ACTN3 and PPARA gene variants with strength phenotypes in middle school-age children

被引：37

作者：

Ahmetov, Ildus I. ^{[1
,2
]}

Gavrilov, Dmitry N. ^{[2
]}

Astratenkova, Irina V. ^{[2
]}

Druzhevskaya, Anastasiya M. ^{[2
]}

Malinin, Alexandr V. ^{[2
]}

Romanova, Elena E. ^{[2
]}

Rogozkin, Victor A. ^{[2
]}

机构：

[1] Volga Reg State Acad Phys Culture Sport & Tourism, Sport Technol Educ Res Lab, Kazan 420138, Russia

[2] St Petersburg Res Inst Phys Culture, St Petersburg 191040, Russia

来源：

JOURNAL OF PHYSIOLOGICAL SCIENCES | 2013年 / 63卷 / 01期

关键词：

Polymorphism; Gene; Genetics; Physiological development; Strength; CONVERTING ENZYME GENOTYPE; MUSCLE STRENGTH; R577X POLYMORPHISM; ADOLESCENT GREEKS; SKELETAL-MUSCLE; ATHLETE STATUS; ALPHA GENE; PERFORMANCE; ALPHA-ACTININ-3; WOMEN;

D O I：

10.1007/s12576-012-0233-8

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The aim of the study was to determine the association between ACE I/D, ACTN3 R577X and PPARA intron 7 G/C gene polymorphisms and strength-related traits in 457 middle school-age children (219 boys and 238 girls; aged 11 +/- A 0.4 years). The assessment of different phenotypes was conducted with a number of performance tests. Gene polymorphisms were determined by PCR. The ACE D allele was associated with high results of standing long-jump test in boys [II 148.3 (16.3) cm, ID 152.6 (19.6) cm, DD 158.2 (19.1) cm; P = 0.037]. The ACTN3 R allele was associated with high results of performance tests in males only in combination with other genes (standing long-jump test: P = 0.021; handgrip strength test: P < 0.0001). Furthermore, the male carriers of the PPARA gene C allele demonstrated the best results of handgrip strength testing than GG homozygotes [GG 14.6 (4.0) kg, GC/CC 15.7 (4.3) kg; P = 0.048]. Thus, the ACE, ACTN3 and PPARA gene variants are associated with strength-related traits in physically active middle school-age boys.

引用

页码：79 / 85

页数：7

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