Bone Tissue Engineering: 3D PCL-based nanocomposite scaffolds with tailored properties

被引：54

作者：

Ronca, Dante ^{[1
]}

Langella, Francesco ^{[1
]}

Chierchia, Marianna ^{[1
]}

D'Amora, Ugo ^{[2
]}

Russo, Teresa ^{[2
]}

Domingos, Marco ^{[3
]}

Gloria, Antonio ^{[1
]}

Bartolo, Paulo ^{[3
]}

Ambrosio, Luigi ^{[4
]}

机构：

[1] Univ Naples 2, Inst Orthopaed & Traumathol, Via L De Crecchio 2-4, I-80138 Naples, Italy

[2] Natl Res Council Italy, Inst Polymers Composites & Biomat, Vle JF Kennedy 54, I-80125 Naples, Italy

[3] Univ Manchester, Sch Mech Aerosp & Civil Engn, 113 Princess St, Manchester, Lancs, England

[4] Natl Res Council Italy, Dept Chem Sci & Mat Technol, Piazzale Aldo Moro 7, I-00185 Rome, Italy

来源：

SECOND CIRP CONFERENCE ON BIOMANUFACTURING | 2016年 / 49卷

关键词：

Bone; Tissue Regeneration; Nanocomposite Scaffolds; Additive Manufacturing; MAGNETIC SCAFFOLDS; MECHANICAL-PROPERTIES; INJECTABLE MATERIALS; COMPOSITE-MATERIALS; CELL; REGENERATION; HYDROGELS; DELIVERY; COLLAGEN;

D O I：

10.1016/j.procir.2015.07.028

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In the field of reconstructive surgery, a great challenge is represented by bone injuries beyond the self-repair threshold. Autologous bone grafts may be considered the gold standard. Anyway, such approach is limited by the amount of tissue required for grafting and by donor site morbidity. To overcome these drawbacks, bone tissue engineering represents a promising solution. 3D fully biodegradable and nanocomposite scaffolds for bone tissue regeneration, consisting of poly(epsilon-caprolactone) (PCL) reinforced with hydroxyapatite (HA) nanoparticles, were developed using an additive manufacturing process. The effect of nanoparticles and architecture (i.e., lay-down pattern) on the mechanical/functional and biological properties was discussed. (C) 2015 The Authors. Published by Elsevier B.V.

引用

页码：51 / 54

页数：4

共 31 条

[1] Layer-by-Layer Self-Assembly of Chitosan and Poly(γ-glutamic acid) into Polyelectrolyte Complexes [J].

Antunes, Joana C. ;

Pereira, Catarina Leite ;

Molinos, Maria ;

Ferreira-da-Silva, Frederico ;

Dessi, Mariagemiliana ;

Gloria, Antonio ;

Ambrosio, Luigi ;

Goncalves, Raquel M. ;

Barbosa, Mario A. .

BIOMACROMOLECULES, 2011, 12 (12) :4183-4195

[2] Poly(caprolactone) based magnetic scaffolds for bone tissue engineering [J].

Banobre-Lopez, M. ;

Pineiro-Redondo, Y. ;

De Santis, R. ;

Gloria, A. ;

Ambrosio, L. ;

Tampieri, A. ;

Dediu, V. ;

Rivas, J. .

JOURNAL OF APPLIED PHYSICS, 2011, 109 (07)

[3] CONTRIBUTION OF COLLAGEN AND MINERAL TO ELASTIC-PLASTIC PROPERTIES OF BONE [J].

BURSTEIN, AH ;

ZIKA, JM ;

HEIPLE, KG ;

KLEIN, L .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1975, 57 (07) :956-961

[4] Continuous fibre reinforced polymers as connective tissue replacement [J].

De Santis, R ;

Sarracino, F ;

Mollica, F ;

Netti, PA ;

Ambrosio, L ;

Nicolais, L .

COMPOSITES SCIENCE AND TECHNOLOGY, 2004, 64 (06) :861-871

[5] Advanced composites for hard-tissue engineering based on PCL/organic-inorganic hybrid fillers: From the design of 2D substrates to 3D rapid prototyped scaffolds [J].

De Santis, R. ;

Gloria, A. ;

Russo, T. ;

D'Amora, U. ;

D'Anto, V. ;

Bollino, F. ;

Catauro, M. ;

Mollica, F. ;

Rengo, S. ;

Ambrosio, L. .

POLYMER COMPOSITES, 2013, 34 (09) :1413-1417

[6] A Basic Approach Toward the Development of Nanocomposite Magnetic Scaffolds for Advanced Bone Tissue Engineering [J].

De Santis, R. ;

Gloria, A. ;

Russo, T. ;

D'Amora, U. ;

Zeppetelli, S. ;

Dionigi, C. ;

Sytcheva, A. ;

Herrmannsdoerfer, T. ;

Dediu, V. ;

Ambrosio, L. .

JOURNAL OF APPLIED POLYMER SCIENCE, 2011, 122 (06) :3599-3605

[7] Towards the Design of 3D Fiber-Deposited Poly(ε-caprolactone)/Iron-Doped Hydroxyapatite Nanocomposite Magnetic Scaffolds for Bone Regeneration [J].

De Santis, Roberto ;

Russo, Alessandro ;

Gloria, Antonio ;

D'Amora, Ugo ;

Russo, Teresa ;

Panseri, Silvia ;

Sandri, Monica ;

Tampieri, Anna ;

Marcacci, Maurilio ;

Dediu, Valentin A. ;

Wilde, Colin J. ;

Ambrosio, Luigi .

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2015, 11 (07) :1236-1246

[8] The first systematic analysis of 3D rapid prototyped poly(ε-caprolactone) scaffolds manufactured through BioCell printing: the effect of pore size and geometry on compressive mechanical behaviour and in vitro hMSC viability [J].

Domingos, M. ;

Intranuovo, F. ;

Russo, T. ;

De Santis, R. ;

Gloria, A. ;

Ambrosio, L. ;

Ciurana, J. ;

Bartolo, P. .

BIOFABRICATION, 2013, 5 (04)

[9] Improved osteoblast cell affinity on plasma-modified 3-D extruded PCL scaffolds [J].

Domingos, M. ;

Intranuovo, F. ;

Gloria, A. ;

Gristina, R. ;

Ambrosio, L. ;

Bartolo, P. J. ;

Favia, P. .

ACTA BIOMATERIALIA, 2013, 9 (04) :5997-6005

[10] Effect of process parameters on the morphological and mechanical properties of 3D Bioextruded poly(ε-caprolactone) scaffolds [J].

Domingos, M. ;

Chiellini, F. ;

Gloria, A. ;

Ambrosio, L. ;

Bartolo, P. ;

Chiellini, E. .

RAPID PROTOTYPING JOURNAL, 2012, 18 (01) :56-67

← 1 2 3 4 →