In-a-Dish: Induced Pluripotent Stem Cells as a Novel Model for Human Diseases

被引：15
作者：
Beltrao-Braga, P. C. B. [1 ,2 ]
Pignatari, G. C. [1 ]
Russo, F. B. [1 ]
Fernandes, I. R. [1 ]
Muotri, A. R. [1 ,3 ,4 ]
机构：
[1] Univ Sao Paulo, Surg Dept, Stem Cell Lab, Sch Vet Med, Sao Paulo, Brazil
[2] Univ Sao Paulo, Obstet Dept, Sch Arts Sci & Humanities, Sao Paulo, Brazil
[3] Univ Calif San Diego, Dept Pediat, Rady Childrens Hosp San Diego, Sch Med,Stem Cell Program, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Dept Cellular & Mol Med, Sch Med, Stem Cell Program, La Jolla, CA 92093 USA
来源：
CYTOMETRY PART A | 2013年 / 83A卷 / 01期
关键词：
induced pluripotent stem cell; disease modeling; reprogramming; neurological diseases; HUMAN FIBROBLASTS; GENE-EXPRESSION; IPS CELLS; GENERATION; LINES; OCT4; NANOG; MOUSE; DIFFERENTIATION; DERIVATION;
D O I：
10.1002/cyto.a.22231
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Human pluripotent stem cells bring promise in regenerative medicine due to their self-renewing ability and the potential to become any cell type in the body. Moreover, pluripotent stem cells can produce specialized cell types that are affected in certain diseases, generating a new way to study cellular and molecular mechanisms involved in the disease pathology under the controlled conditions of a scientific laboratory. Thus, induced pluripotent stem cells (iPSC) are already being used to gain insights into the biological mechanisms of several human disorders. Here we review the use of iPSC as a novel tool for disease modeling in the lab. (C) 2012 International Society for Advancement of Cytometry
引用
收藏
页码：11 / 17
页数：7
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