Bioconjugation Using Thiols: Old Chemistry Rediscovered to Connect Polymers with Nature's Building Blocks

被引：153
作者：
Stenzel, Martina H. [1 ]
机构：
[1] Univ New S Wales, Sch Chem Engn, CAMD, Sydney, NSW 2052, Australia
来源：
ACS MACRO LETTERS | 2013年 / 2卷 / 01期
基金：
澳大利亚研究理事会;
关键词：
POST-POLYMERIZATION MODIFICATION; CHAIN TRANSFER POLYMERIZATION; RADICAL POLYMERIZATION; CHEMICAL-MODIFICATION; ENE CLICK; CONJUGATION; PEPTIDE; SIRNA; FUNCTIONALIZATION; COPOLYMERS;
D O I：
10.1021/mz3005814
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Various pathways to bioconjugates based on thiol chemistry are discussed. Thiol-halogeno, thiol-parafluoro, thiol-ene, thiol-yne, thiol-vinylsulfone and thiol-vinyl sulfone, thiol-maleimide, thiol-bisulfone, and thiol-pyridyl disulfide are well-established synthetic routes discovered in recent years as tools to marry polymers with biomolecules such as carbohydrates, proteins, peptide, DNA, antibodies, or other building blocks from nature.
引用
收藏
页码：14 / 18
页数：5
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