Preparation and characterization of polymeric nanoparticles composed of poly(DL-lactide-co-glycolide) and poly(DL-lactide-co-glycolide)-co-poly(ethylene glycol)-10%-Triblock end-capped with a galactose moiety

被引：19
|
作者：
Peca, Ines N. [1 ]
Petrova, Krasimira T. [1 ]
Margarida Cardoso, M. [1 ]
Teresa Barros, M. [1 ]
机构：
[1] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE,CQFB, P-2829516 Quinta Da Torre, Caparica, Portugal
来源：
REACTIVE & FUNCTIONAL POLYMERS | 2012年 / 72卷 / 10期
关键词：
Drug delivery; Liver-specific drug carrier; Nanoparticles; Polymeric conjugates; Galactosylated PLGA; DRUG-DELIVERY; N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERS; HEPATOMA-CELLS; CANCER-THERAPY; POLYSTYRENE; RESIDUES; CULTURE; CARRIER; SYSTEM;
D O I：
10.1016/j.reactfunctpolym.2012.06.019
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
This work aimed at the synthesis of novel type of targetable polymeric conjugates with a sugar moiety (galactose) with potential application for liver-specific drug delivery. Simple and effective synthesis of poly(DL-lactide-co-glycolide)-galactose conjugate and poly(DL-lactide-co-glycolide)-co-poly(ethylene glycol)-10%-Triblock-galactose conjugate by esterification of the end carboxyl groups has been reported. Spherical hydrophilic nanoparticles with elevated galactose content on the surface were prepared from these polymeric conjugates, and their physical properties were determined by DLS, SEM, XPS and DSC. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：729 / 735
页数：7
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