Reactive Oxygen Species and Antitumor Immunity-From Surveillance to Evasion

被引：98

作者：

Kotsafti, Andromachi ^{[1
]}

Scarpa, Marco ^{[2
]}

Castagliuolo, Ignazio ^{[3
]}

Scarpa, Melania ^{[1
]}

机构：

[1] Veneto Inst Oncol IOV IRCCS, Lab Adv Translat Res, I-35128 Padua, Italy

[2] Azienda Osped Padova, Gen Surg Unit, I-35128 Padua, Italy

[3] Univ Padua, Dept Mol Med DMM, I-35121 Padua, Italy

来源：

CANCERS | 2020年 / 12卷 / 07期

关键词：

reactive oxygen species; oxidative stress; immunity; inflammation; cancer; T-CELL-ACTIVATION; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; SUPPRESSOR-CELLS; TUMOR MICROENVIRONMENT; MITOCHONDRIAL BIOGENESIS; NADPH OXIDASE; MYELOID CELLS; CANCER; ANTIGEN;

D O I：

10.3390/cancers12071748

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The immune system is a crucial regulator of tumor biology with the capacity to support or inhibit cancer development, growth, invasion and metastasis. Emerging evidence show that reactive oxygen species (ROS) are not only mediators of oxidative stress but also players of immune regulation in tumor development. This review intends to discuss the mechanism by which ROS can affect the anti-tumor immune response, with particular emphasis on their role on cancer antigenicity, immunogenicity and shaping of the tumor immune microenvironment. Given the complex role that ROS play in the dynamics of cancer-immune cell interaction, further investigation is needed for the development of effective strategies combining ROS manipulation and immunotherapies for cancer treatment.

引用

页码：1 / 16

页数：16

共 127 条

[1] Oxidative stress modulates the cytokine response of differentiated Th17 and Th1 cells [J].

Abimannan, Thiruvaimozhi ;

Peroumal, Doureradjou ;

Parida, Jyoti R. ;

Barik, Prakash K. ;

Padhan, Prasanta ;

Devadas, Satish .

FREE RADICAL BIOLOGY AND MEDICINE, 2016, 99 :352-363

[2] Reactive Oxygen Species, Granulocytes, and NETosis [J].

Arazna, Magdalena ;

Pruchniak, Michal P. ;

Demkow, Urszula .

RESPIRATORY VIROLOGY AND IMMUNOGENICITY, 2015, 836 :1-7

[3] Role of NOX2-Derived Reactive Oxygen Species in NK Cell-Mediated Control of Murine Melanoma Metastasis [J].

Aydin, Ebru ;

Johansson, Junko ;

Nazir, Faisal Hayat ;

Hellstrand, Kristoffer ;

Martner, Anna .

CANCER IMMUNOLOGY RESEARCH, 2017, 5 (09) :804-811

[4] Regulation of PD-L1 expression on cancer cells with ROS-modulating drugs [J].

Bailly, Christian .

LIFE SCIENCES, 2020, 246

[5] Immune Escape Mechanisms as a Guide for Cancer Immunotherapy [J].

Beatty, Gregory L. ;

Gladney, Whitney L. .

CLINICAL CANCER RESEARCH, 2015, 21 (04) :687-692

[6] Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells [J].

Bertini, R ;

Howard, OMZ ;

Dong, HF ;

Oppenheim, JJ ;

Bizzarri, C ;

Sergi, R ;

Caselli, G ;

Pagliei, S ;

Romines, B ;

Wilshire, JA ;

Mengozzi, M ;

Nakamura, H ;

Yodoi, J ;

Pekkari, K ;

Gurunath, R ;

Holmgren, A ;

Herzenberg, LA ;

Ghezzi, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (11) :1783-1789

[7] B- to Plasma-Cell Terminal Differentiation Entails Oxidative Stress and Profound Reshaping of the Antioxidant Responses [J].

Bertolotti, Milena ;

Yim, Sun Hee ;

Garcia-Manteiga, Jose M. ;

Masciarelli, Silvia ;

Kim, Yoo-Jin ;

Kang, Min-Hee ;

Iuchi, Yoshihito ;

Fujii, Junichi ;

Vene, Roberta ;

Rubartelli, Anna ;

Rhee, Sue Goo ;

Sitia, Roberto .

ANTIOXIDANTS & REDOX SIGNALING, 2010, 13 (08) :1133-1144

[8] The determinants of tumour immunogenicity [J].

Blankenstein, Thomas ;

Coulie, Pierre G. ;

Gilboa, Eli ;

Jaffee, Elizabeth M. .

NATURE REVIEWS CANCER, 2012, 12 (04) :307-313

[9] L-arginine metabolism in myeloid cells controls T-lymphocyte functions [J].

Bronte, V ;

Serafini, P ;

Mazzoni, A ;

Segal, DM ;

Zanovello, P .

TRENDS IN IMMUNOLOGY, 2003, 24 (06) :302-306

[10] Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [J].

Bronte, Vincenzo ;

Brandau, Sven ;

Chen, Shu-Hsia ;

Colombo, Mario P. ;

Frey, Alan B. ;

Greten, Tim F. ;

Mandruzzato, Susanna ;

Murray, Peter J. ;

Ochoa, Augusto ;

Ostrand-Rosenberg, Suzanne ;

Rodriguez, Paulo C. ;

Sica, Antonio ;

Umansky, Viktor ;

Vonderheide, Robert H. ;

Gabrilovich, Dmitry I. .

NATURE COMMUNICATIONS, 2016, 7

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