Looking for selectivity among cytochrome P450s inhibitors

被引：23

作者：

Cavalli, A ^{[1
]}

Recanatini, M ^{[1
]}

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 45卷 / 02期

关键词：

D O I：

10.1021/jm015567k

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cytochrome P450s 19 and 17 are very important pharmacological targets in two different fields of cancer chemotherapy. We present here a theoretical study aimed at explaining the molecular basis of inhibitor affinity and selectivity for either P450 19 or P450 17. Docking simulations of two compounds pointed out the major physicochemical features associated with inhibitory activity. Our results, in agreement with site-directed mutagenesis experiments, could be of relevant utility when designing new P450 19 and P450 17 inhibitors.

引用

页码：251 / 254

页数：4

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