The first wave: HCV NS3 protease inhibitors telaprevir and boceprevir

被引：26

作者：

Marks, Kristen M. ^{[1
]}

Jacobson, Ira M. ^{[2
]}

机构：

[1] Weill Cornell Med Coll, Div Infect Dis, New York, NY USA

[2] Weill Cornell Med Coll, Div Gastroenterol & Hepatol, New York, NY USA

来源：

ANTIVIRAL THERAPY | 2012年 / 17卷 / 06期

关键词：

HEPATITIS-C; TREATMENT-NAIVE; PEGINTERFERON ALPHA-2B/RIBAVIRIN; ANTIVIRAL ACTIVITY; RIBAVIRIN; RESISTANCE; VX-950; SCH-503034; ANEMIA; RNA;

D O I：

10.3851/IMP2424

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Boceprevir and telaprevir are peptidomimetic serine protease inhibitors that have been recently approved for the treatment of HCV chronic infection. The addition of these drugs to the prior standard of care, pegylated interferon and ribavirin, improves sustained virological response rates for treatment-naive and treatment-experienced patients and shortens the duration of treatment for over half of treatment-naive patients. This review describes the clinical data supporting the approval and use of telaprevir and boceprevir, the algorithm for the use of these drugs, their adverse effects, as well as their important drug-drug interactions.

引用

页码：1119 / 1131

页数：13

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