Synthesis of 3-Amino-2-carboxamide Tetrahydropyrrolo[2,3-b]quinolines

被引：7

作者：

Pilkington, Lisa I. ^{[1
]}

Haverkate, Natalie A. ^{[1
]}

Van Rensburg, Michelle ^{[1
]}

Reynisson, Johannes ^{[1
]}

Leung, Euphemia ^{[2
,3
]}

Barker, David ^{[1
]}

机构：

[1] Univ Auckland, Sch Chem Sci, Private Bag 92019, Auckland 1142, New Zealand

[2] Univ Auckland, Auckland Canc Soc Res Ctr, Private Bag 92019, Auckland 1142, New Zealand

[3] Univ Auckland, Dept Mol Med & Pathol, Private Bag 92019, Auckland 1142, New Zealand

来源：

SYNLETT | 2016年 / 27卷 / 20期

关键词：

pyrrolo[2,3-b]quinolines; Thorpe-Ziegler; pyrrolo[2,3-b]pyridines; thieno[2,3-b]pyridines; heterocycles; DERIVATIVES; INHIBITORS; IDENTIFICATION; CYTOTOXICITY; CELLS;

D O I：

10.1055/s-0036-1588619

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This article communicates the first synthesis of 3-amino-2-carboxamide pyrrolo[2,3-b]quinolines and fused-ring pyrrolopyridines in an efficient synthesis via a Thorpe-Ziegler transformation. The reported synthetic route allows for a wide range of nitrogen analogues of thienopyridines - compounds which have potent bioactivities but poor aqueous solubility.

引用

页码：2811 / 2814

页数：4

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