Tissue Engineering Under Microgravity Conditions-Use of Stem Cells and Specialized Cells

被引:73
作者
Grimm, Daniela [1 ,2 ]
Egli, Marcel [3 ]
Krueger, Marcus [2 ]
Riwaldt, Stefan [1 ]
Corydon, Thomas J. [1 ,4 ]
Kopp, Sascha [2 ]
Wehland, Markus [2 ]
Wise, Petra [5 ]
Infanger, Manfred [2 ]
Mann, Vivek [6 ]
Sundaresan, Alamelu [6 ]
机构
[1] Aarhus Univ, Dept Biomed, Aarhus C, Denmark
[2] Otto von Guericke Univ, Clin Plast Aesthet & Hand Surg, Magdeburg, Germany
[3] Lucerne Univ Appl Sci & Arts, Inst Med Engn, Hergiswil, Switzerland
[4] Aarhus Univ Hosp, Dept Ophthalmol, Aarhus, Denmark
[5] Univ Southern Calif, Childrens Hosp Los Angeles, Hematol Oncol, Los Angeles, CA USA
[6] Texas Southern Univ, Dept Biol, Houston, TX USA
关键词
microgravity; multicellular spheroids; tissue engineering; organoids; stem cells; random positioning machine; rotating wall vessel; spaceflight; HUMAN ENDOTHELIAL-CELLS; INHIBITS OSTEOGENIC DIFFERENTIATION; THYROID-CARCINOMA CELLS; BONE-MARROW-CELLS; SIMULATED MICROGRAVITY; 3-DIMENSIONAL GROWTH; SPHEROID FORMATION; CULTURE-SYSTEM; CHONDROGENIC DIFFERENTIATION; PIGMENT-EPITHELIUM;
D O I
10.1089/scd.2017.0242
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Experimental cell research studying three-dimensional (3D) tissues in space and on Earth using new techniques to simulate microgravity is currently a hot topic in Gravitational Biology and Biomedicine. This review will focus on the current knowledge of the use of stem cells and specialized cells for tissue engineering under simulated microgravity conditions. We will report on recent advancements in the ability to construct 3D aggregates from various cell types using devices originally created to prepare for spaceflights such as the random positioning machine (RPM), the clinostat, or the NASA-developed rotating wall vessel (RWV) bioreactor, to engineer various tissues such as preliminary vessels, eye tissue, bone, cartilage, multicellular cancer spheroids, and others from different cells. In addition, stem cells had been investigated under microgravity for the purpose to engineer adipose tissue, cartilage, or bone. Recent publications have discussed different changes of stem cells when exposed to microgravity and the relevant pathways involved in these biological processes. Tissue engineering in microgravity is a new technique to produce organoids, spheroids, or tissues with and without scaffolds. These 3D aggregates can be used for drug testing studies or for coculture models. Multicellular tumor spheroids may be interesting for radiation experiments in the future and to reduce the need for in vivo experiments. Current achievements using cells from patients engineered on the RWV or on the RPM represent an important step in the advancement of techniques that may be applied in translational Regenerative Medicine.
引用
收藏
页码:787 / 804
页数:18
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