Type I interferons: diversity of sources, production pathways and effects on immune responses

被引：102
作者：
Swiecki, Melissa [1 ]
Colonna, Marco [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
来源：
CURRENT OPINION IN VIROLOGY | 2011年 / 1卷 / 06期
基金：
美国国家卫生研究院;
关键词：
PLASMACYTOID DENDRITIC CELLS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; DOUBLE-STRANDED-RNA; TOLL-LIKE RECEPTORS; SUBCAPSULAR SINUS MACROPHAGES; PATTERN-RECOGNITION RECEPTORS; DEPENDENT VIRAL RECOGNITION; IRF3 TRANSCRIPTION FACTOR; HERPES-SIMPLEX-VIRUS; IFN-BETA PROMOTER;
D O I：
10.1016/j.coviro.2011.10.026
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune responses to viruses are also greatly influenced by IFN-I. In this article we discuss the diversity of cellular sources of IFN-I and the pathways leading to IFN-I production during viral infections. Finally, we discuss the effects of IFN-I on cells of the immune system with emphasis on dendritic cells.
引用
收藏
页码：463 / 475
页数：13
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