The Pharmacist's Role in Treating Extended-Spectrum Beta-Lactamase Infections

被引：0

作者：

Singleton, Abby ^{[1
]}

Cluck, David ^{[1
]}

机构：

[1] East Tennessee State Univ, Pharm Practice, Johnson City, TN 37614 USA

来源：

US PHARMACIST | 2019年 / 44卷 / 04期

关键词：

ESCHERICHIA-COLI; ENTEROBACTERIACEAE; NITROFURANTOIN; RESISTANCE; FOSFOMYCIN;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The production of a beta-lactamase- a type pi bacterial enzyme-is the most common mechanism of resistance to beta-lactam antibiotics among gram-negative bacteria. Extended-spectrum beta-lactamases (ESBLs) hydrolyze most penicillins, extended-spectrum cephalosporins, and aztreonam. Infections due to ESBL-producing organisms are associated with increased mortality. Once an ESBL is detected, appropriate treatment is important in order to ensure optimal patient outcomes. Infections caused by ESBLs are challenging to treat for various reasons, including difficulty in detecting ESBL-producing organisms as well as mixed data on how to best treat these infections. The increasing worldwide prevalence of infections caused by ESBL-producing organisms highlights the importance of antimicrobial-stewardship programs to promote appropriate use of antibiotics and lessen the risk of subsequent development of resistance.

引用

页码：HS2 / HS6

页数：5

共 25 条

[1] Extended-spectrum β-lactamases in the 21st century:: Characterization, epidemiology, and detection of this important resistance threat [J].

Bradford, PA .

CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (04) :933-951

[2]

Curello Jennifer, 2014, J Pediatr Pharmacol Ther, V19, P156, DOI 10.5863/1551-6776-19.3.156

[3] Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011 [J].

Fleming-Dutra, Katherine E. ;

Hersh, Adam L. ;

Shapiro, Daniel J. ;

Bartoces, Monina ;

Enns, Eva A. ;

File, Thomas M., Jr. ;

Finkelstein, Jonathan A. ;

Gerber, Jeffrey S. ;

Hyun, David Y. ;

Linder, Jeffrey A. ;

Lynfield, Ruth ;

Margolis, David J. ;

May, Larissa S. ;

Merenstein, Daniel ;

Metlay, Joshua P. ;

Newland, Jason G. ;

Piccirillo, Jay F. ;

Roberts, Rebecca M. ;

Sanchez, Guillermo V. ;

Suda, Katie J. ;

Thomas, Ann ;

Woo, Teri Moser ;

Zetts, Rachel M. ;

Hicks, Lauri A. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (17) :1864-1873

[4] Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance A Randomized Clinical Trial [J].

Harris, Patrick N. A. ;

Tambyah, Paul A. ;

Lye, David C. ;

Mo, Yin ;

Lee, Tau H. ;

Yilmaz, Mesut ;

Alenazi, Tamer H. ;

Arabi, Yaseen ;

Falcone, Marco ;

Bassetti, Matteo ;

Righi, Elda ;

Rogers, Benjamin A. ;

Kanj, Souha ;

Bhally, Hasan ;

Iredell, Jon ;

Mendelson, Marc ;

Boyles, Tom H. ;

Looke, David ;

Miyakis, Spiros ;

Walls, Genevieve ;

Al Khamis, Mohammed ;

Zikri, Ahmed ;

Crowe, Amy ;

Ingram, Paul ;

Daneman, Nick ;

Griffin, Paul ;

Athan, Eugene ;

Lorenc, Penelope ;

Baker, Peter ;

Roberts, Leah ;

Beatson, Scott A. ;

Peleg, Anton Y. ;

Harris-Brown, Tiffany ;

Paterson, David L. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 320 (10) :984-994

[5] Ertapenem resistance of Escherichia coli [J].

Lartigue, Marie-Frederique ;

Poirel, Laurent ;

Poyart, Claire ;

Reglier-Poupet, Helene ;

Nordmann, Patrice .

EMERGING INFECTIOUS DISEASES, 2007, 13 (02) :315-317

[6] Epidemiology and Clinical Features of Community-Onset Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae [J].

Lee, Jeong-a ;

Kang, Cheol-In ;

Joo, Eun-Jeong ;

Ha, Young Eun ;

Kang, Seung-Ji ;

Park, So Yeon ;

Chung, Doo Ryeon ;

Peck, Kyong Ran ;

Ko, Kwan Soo ;

Lee, Nam Yong ;

Song, Jae-Hoon .

MICROBIAL DRUG RESISTANCE, 2011, 17 (02) :267-273

[7] Incidence of Extended-Spectrum -Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review [J].

McDanel, Jennifer ;

Schweizer, Marin ;

Crabb, Victoria ;

Nelson, Richard ;

Samore, Matthew ;

Khader, Karim ;

Blevins, Amy E. ;

Diekema, Daniel ;

Chiang, Hsiu-Yin ;

Nair, Rajeshwari ;

Perencevich, Eli .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2017, 38 (10) :1209-1215

[8] Antibiotic therapy for Klebsiella pneumoniae bacteremia:: Implications of production of extended-spectrum β-lactamases [J].

Paterson, DL ;

Ko, WC ;

Von Gottberg, A ;

Mohapatra, S ;

Casellas, JM ;

Goossens, H ;

Mulazimoglu, L ;

Trenholme, G ;

Klugman, KP ;

Bonomo, RA ;

Rice, LB ;

Wagener, MM ;

McCormack, JG ;

Yu, VL .

CLINICAL INFECTIOUS DISEASES, 2004, 39 (01) :31-37

[9] Extended-spectrum β-lactamase-producing enterobacteriaceae:: an emerging public-health concern [J].

Pitout, Johann D. D. ;

Laupland, Kevin B. .

LANCET INFECTIOUS DISEASES, 2008, 8 (03) :159-166

[10] Fosfomycin for the Treatment of Resistant Gram-Negative Bacterial Infections Insights from the Society of Infectious Diseases Pharmacists [J].

Reffert, Julia L. ;

Smith, Winter J. .

PHARMACOTHERAPY, 2014, 34 (08) :845-857

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