Synthesis of 5,6-Dichloroindan-1-Acids and their Tetrazolyl Derivatives as Analgesic and Anti-inflammatory Agents

被引：0

作者：

Pal, Rajib Kumar ^{[2
]}

Yasmin, Hasina ^{[3
]}

Nahar, Lutfun ^{[4
]}

Datta, Bidyut Kanti ^{[5
]}

Chowdhury, Abul Kalam Azad ^{[6
]}

Kundu, Joydeb Kumar ^{[5
]}

Bachar, Sitesh Chandra ^{[5
]}

Sarker, Satyajit Dey ^{[1
]}

机构：

[1] Wolverhampton Univ, Dept Pharm, Sch Appl Sci, Wolverhampton WV1 1LY, W Midlands, England

[2] NIA, NIH, Baltimore, MD 21224 USA

[3] State Univ Bangladesh, Dept Pharm, Dhaka 1209, Bangladesh

[4] De Montfort Univ, Leicester Sch Pharm, Leicester LE1 9BH, Leics, England

[5] Univ Dhaka, Fac Pharm, Dept Pharmaceut Technol, Dhaka 1000, Bangladesh

[6] Univ Dhaka, Fac Pharm, Dept Clin Pharm & Pharmacol, Dhaka 1000, Bangladesh

来源：

MEDICINAL CHEMISTRY | 2012年 / 8卷 / 05期

关键词：

Indan acids; Indanyl tetrazoles; 5,6-dichloroindan-1-carboxylic acid; 5,6-dichloroindan-1-acetic Acid; 5-(5; 6; '-dichloroindan-1; '-yl)-tetrazole; '-yl)-methyltetrazole; Carrageenan; Analgesic activity; Anti-inflammatory activity; BIOLOGICAL EVALUATION; AMIDE DERIVATIVES; ACID; CARRAGEENIN; RAT; 5-(INDAN-1'-YL)METHYLTETRAZOLES; 5-(INDAN-1'-YL)TETRAZOLES; EDEMA; PAW;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Indan derivatives, namely, 5-(5',6'-dichloroindan-1'-yl)-tetrazole (12a) and 5-(5', 6'-dichloroindan-1'-yl)methyltetrazole (12b), were synthesized conveniently from 5,6-dichloroindan-1-carboxylic acid (9a) and 5,6-dichloroindan-1-acetic acid (9b), respectively, as potential analgesic and anti-inflammatory agents. The analgesic and anti-inflammatory properties of 9a, 9b, 12a and 12b were evaluated by the acetic acid induced writhing in Swiss albino mice and the carrageenan-induced rat paw edema models, respectively. Compounds 9a and 12a exhibited significant analgesic activity with the doses of 50 and 100 mg/kg body weight, comparable to that of the positive controls, phenylbutazone, indomethacin and aminopyrine. The anti-inflammatory potencies of 9a and 12a were also comparable to that of the positive control, phenylbutazone. Compounds 9b and 12b showed analgesic and anti-inflammatory activities, but were weaker than that of compounds 9a and 12a.

引用

页码：874 / 882

页数：9