Tissue factor initiated blood coagulation

被引：35
|
作者：
Gomez, K [1 ]
McVey, JH [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, London W12 0NN, England
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2006年 / 11卷
基金：
英国医学研究理事会;
关键词：
blood; coagulation; tissue factor; factor VII; review;
D O I：
10.2741/1888
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tissue factor (TF) is the cellular receptor and cofactor for blood coagulation factor (F) VII. Exposure of flowing blood to cells that express TF leads to the initiation of blood coagulation. Blood coagulation is tightly regulated to generate a local fibrin clot at the site of vascular injury without compromising blood flow in the vasculature. This chapter describes the initiation and propagation of the response and how it is ultimately down-regulated to prevent widespread inappropriate blood coagulation.
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页码：1349 / 1359
页数：11
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