The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc

被引：54
|
作者：
Kalra, N [1 ]
Kumar, V [1 ]
机构：
[1] Int Ctr Genet Engn & Biotechnol, Virol Grp, New Delhi 110067, India
来源：
FEBS LETTERS | 2006年 / 580卷 / 02期
关键词：
F box protein; X protein of hepatitis B virus; c-Myc; Skp1-cullin1-F box protein complex; Skp2; ubiquitination;
D O I：
10.1016/j.febslet.2005.12.034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The HBx protein of hepatitis B virus is involved in deregulation of cell cycle and development of hepatocellular carcinoma. Since c-Myc also plays an important role in cell proliferation and tumor development, we studied its regulation by HBx in a human hepatoma cell line. Co-expression of HBx and c-Myc resulted in increased stability of intracellular c-Myc. HBx blocked the ubiquitination of Myc through a direct interaction with the F box region of Skp2 and destabilization of the SCFSkp2 Complex. We suggest that sustained presence of c-Myc combined with mitogenic activity inherent to HBx may be associated with cell cycle deregulation and transformation. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：431 / 436
页数：6
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