Alzheimer's disease therapeutic research: the path forward

被引:36
作者
Aisen, Paul S. [1 ]
机构
[1] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
来源
ALZHEIMERS RESEARCH & THERAPY | 2009年 / 1卷 / 01期
关键词
AMYLOID-BETA; COGNITIVE IMPAIRMENT; PHASE-II; DEPOSITION; IMMUNIZATION; A-BETA(42); DIAGNOSIS; TRIALS;
D O I
10.1186/alzrt2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The field of Alzheimer's disease therapeutic research seems poised to bring to clinic the next generation of treatments, moving beyond symptomatic benefits to modification of the underlying neurobiology of the disease. But a series of recent trials has had disappointingly negative results that raise questions about our drug development strategies. Consideration of ongoing programs demonstrates difficult pitfalls. But a clear path forward is emerging. Successful strategies will utilize newly available tools to reconsider issues of diagnosis, assessment and analysis, facilitating the study of new treatments at early stages in the disease process at which they are most likely to yield major clinical benefits.
引用
收藏
页数:6
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