Controlling ionic conductivity through transprotein electropores in human aquaporin 4: a non- equilibrium molecular- dynamics study

被引：10

作者：

Bernardi, Mario ^{[1
]}

Marracino, Paolo ^{[1
]}

Liberti, Micaela ^{[1
]}

Garate, Jose-Antonio ^{[2
]}

Burnham, Christian J. ^{[3
]}

Apollonio, Francesca ^{[1
]}

English, Niall J. ^{[3
]}

机构：

[1] Univ Roma La Sapienza, Dept Informat Engn Elect & Telecommun, I-00184 Rome, Italy

[2] Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso 05101, Chile

[3] Univ Coll Dublin, Sch Chem & Bioproc Engn, Dublin 4, Ireland

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2019年 / 21卷 / 06期

关键词：

MEMBRANE ELECTROPORATION; LIPID-MEMBRANES; CHANNELS; BRAIN; SIMULATIONS; FIELDS; PORES;

D O I：

10.1039/c8cp06643d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Electroporation is a matter of intensive ongoing research interest, and a much-neglected topic in trans-membrane proteins, particularly in view of such promising potential applications in medicine and biotechnology. In particular, selected such novel and exciting applications are predicated on controlling ionic conductivity through electro-pores. Here, we scrutinise the mechanisms of ions' electric conductivity, by means of structural rearrangements, through quasi-stable electro-pores through human-AQP4 as a well-representative prototype of trans-membrane ionic conduction, achieving exquisite control over ionic permeability manipulated by the application of intense static electric fields.

引用

页码：3339 / 3346

页数：8

共 52 条

[1]

Allen M. P., 2017, COMPUTER SIMULATION

[2]

[Anonymous], 2012, INTRO MATH STAT

[3] Aquaporin 4 as a NH3 Channel [J].

Assentoft, Mette ;

Kaptan, Shreyas ;

Schneider, Hans-Peter ;

Deitmer, Joachim W. ;

de Groot, Bert L. ;

MacAulay, Nanna .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (36) :19184-19195

[4] Aquaporins in brain: Distribution, physiology, and pathophysiology [J].

Badaut, T ;

Lasbennes, T ;

Magistretti, PJ ;

Regli, L .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2002, 22 (04) :367-378

[5] Targeted drug delivery to tumors: Myths, reality and possibility [J].

Bae, You Han ;

Park, Kinam .

JOURNAL OF CONTROLLED RELEASE, 2011, 153 (03) :198-205

[6] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].

BERNSTEIN, FC ;

KOETZLE, TF ;

WILLIAMS, GJB ;

MEYER, EF ;

BRICE, MD ;

RODGERS, JR ;

KENNARD, O ;

SHIMANOUCHI, T ;

TASUMI, M .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) :535-542

[7] Cellular and molecular biology of the aquaporin water channels [J].

Borgnia, M ;

Nielsen, S ;

Engel, A ;

Agre, P .

ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :425-458

[8] First-passage-time analysis of atomic-resolution simulations of the ionic transport in a bacterial porin [J].

Calero, Carles ;

Faraudo, Jordi ;

Aguilella-Arzo, Marcel .

PHYSICAL REVIEW E, 2011, 83 (02)

[9] A molecular dynamic study of cholesterol rich lipid membranes: comparison of electroporation protocols [J].

Casciola, M. ;

Bonhenry, D. ;

Liberti, M. ;

Apollonio, F. ;

Tarek, M. .

BIOELECTROCHEMISTRY, 2014, 100 :11-17

[10] Properties of lipid electropores I: Molecular dynamics simulations of stabilized pores by constant charge imbalance [J].

Casciola, Maura ;

Kasimova, Marina A. ;

Rems, Lea ;

Zullino, Sara ;

Apollonio, Francesca ;

Tarek, Mounir .

BIOELECTROCHEMISTRY, 2016, 109 :108-116

← 1 2 3 4 5 6 →