BackgroundPacked red blood cell transfusion is common in preterm neonates. Hepcidin acts as a negative feedback iron regulator. Iron parameters such as immature reticulocyte fraction (IRF) and high-light-scatter reticulocytes (HLR) are used to clarify iron metabolism. Very little is known about the regulation of hepcidin in preterm infants because most reports have evaluated prohepcidin. The aim of this study was therefore to evaluate serum hepcidin and establish hematological parameters in preterm infants after transfusion. MethodsThe subjects consisted of 19 newborns (10 boys) with mean gestational age 29.1 2.0 weeks, who had been transfused at the chronological age of 44.84 19.61 days. Blood sample was collected before the transfusion and thereafter at 5days and at 1month. Serum hepcidin and other iron parameters were evaluated. ResultsMean serum hepcidin before and 5days after transfusion was significantly different (5.5 +/- 5.1 vs 10 +/- 7.9 ng/mL respectively, P = 0.005). IRF and % HLR were also decreased significantly, 5days after transfusion (0.4 +/- 0.2 vs 0.2 +/- 0.1, P = 0.009; 1.4 +/- 1.5% vs 0.5 +/- 0.4%, P = 0.012, respectively). Changes in hepcidin 5days after transfusion were correlated significantly with changes in mean corpuscular hemoglobin (, 0.13; SE, 0.05; P = 0.017), total iron binding capacity (, 3.74; SE, 1.56; P = 0.016) and transferrin (, 2.9, SE, 1.4; P = 0.039). ConclusionsSerum hepcidin concentration, along with IRF and HLR, are potentially useful in estimating pre- and post-transfusion iron status. Larger studies are needed to evaluate the sensitivity and specificity of hepcidin compared with ordinary iron parameters in premature infants.
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Intrins Lifesci LLC, La Jolla, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Ganz, Tomas
Olbina, Gordana
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Intrins Lifesci LLC, La Jolla, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Olbina, Gordana
Girelli, Domenico
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Univ Verona, Dept Clin & Expt Med, I-37100 Verona, ItalyUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Girelli, Domenico
Nemeth, Elizabeta
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Intrins Lifesci LLC, La Jolla, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Nemeth, Elizabeta
Westerman, Mark
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Intrins Lifesci LLC, La Jolla, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Intrins Lifesci LLC, La Jolla, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Ganz, Tomas
Olbina, Gordana
论文数: 0引用数: 0
h-index: 0
机构:
Intrins Lifesci LLC, La Jolla, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Olbina, Gordana
Girelli, Domenico
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h-index: 0
机构:
Univ Verona, Dept Clin & Expt Med, I-37100 Verona, ItalyUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Girelli, Domenico
Nemeth, Elizabeta
论文数: 0引用数: 0
h-index: 0
机构:
Intrins Lifesci LLC, La Jolla, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Nemeth, Elizabeta
Westerman, Mark
论文数: 0引用数: 0
h-index: 0
机构:
Intrins Lifesci LLC, La Jolla, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA