Neoechinulin A protects PC12 cells against MPP+-induced cytotoxicity

被引：26

作者：

Kajimura, Yoshihito ^{[1
]}

Aoki, Toshiaki ^{[2
]}

Kuramochi, Kouji ^{[1
]}

Kobayashi, Susumu ^{[2
]}

Sugawara, Fumio ^{[1
]}

Watanabe, Nobuo ^{[1
]}

Arai, Takao ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Sci & Technol, Dept Appl Biol Sci, Chiba 2788510, Japan

[2] Tokyo Univ Sci, Dept Pharmaceut Sci, Chiba 2788510, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 05期

关键词：

alkaloid; reactive oxygen/nitrogen species; neurodegeneration; Parkinson's disease;

D O I：

10.1038/ja.2008.48

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Neoechinulin A, an alkaloid from Eurotium rubrum, can protect neuronal PC12 cells against cytotoxicity of a potent oxidant, peroxynitrite. Because involvement of peroxynitrite has been suggested in the pathogenesis of Parkinson's disease, we assessed whether this alkaloid could also protect PC12 cells from the cytocidal action of 1-methyl-4-phenylpyridine (MPP(+)), a neurotoxin capable of provoking acute Parkinson's-like neurodegeneration in humans. Neoechinulin A could protect PC12 cells from MPP(+) cytotoxicity without protecting against mitochondrial complex I dysfunction, suggesting the alkaloid can ameliorate downstream events of mitochondrial failure. Thus, neoechinulin A has the potential to intervene in this progressive neurodegeneration.

引用

页码：330 / 333

页数：4

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