The protective effect of cyclosporine A on anti-Fas antibody-induced hepatitis in mice

被引：7

作者：

Okamoto, T ^{[1
]}

Hitomi, Y ^{[1
]}

Hara, A ^{[1
]}

机构：

[1] Nippon Chemiphar Co Ltd, Res Labs, Misato, Saitama 3410005, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1999年 / 79卷 / 04期

关键词：

Fas; cyclosporine A; liver;

D O I：

10.1254/jjp.79.485

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of cyclosporine A (CsA) on anti-Fas antibody-induced hepatitis was studied. The administration of anti-Fas antibody (250 mu g/kg) to mice elevated plasma alanine aminotransferase (ALT) activity at 3 hr. This anti-Fas antibody-induced elevation of ALT was inhibited by treatment with CsA (10, 30 and 100 mg/kg) in a dose-dependent manner. Anti-Fas antibody administration elevated CPP32-like protease activity at 3 hr in mouse liver, and this elevation of CPP32-like activity was inhibited by treatment with CsA. The present results show that CsA treatment inhibits the anti-Fas antibody-induced apoptotic process of hepatitis, at least in part, by affecting a reaction upstream of CPP32-like protease activation.

引用

页码：485 / 488

页数：4

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