Idelalisib-rituximab induces durable remissions in TP53 disrupted B-PLL but results in significant toxicity: updated results of the UK-wide compassionate use programme

被引：20

作者：

Eyre, Toby A. ^{[1
]}

Fox, Christopher P. ^{[2
]}

Boden, Ali ^{[3
]}

Bloor, Adrian ^{[4
]}

Dungawalla, Moez ^{[5
]}

Shankara, Paneesha ^{[6
]}

Went, Richard ^{[7
]}

Schuh, Anna H. ^{[1
,8
,9
]}

机构：

[1] Oxford Univ Hosp NHS Trust, Churchill Hosp, Dept Haematol, Oxford, England

[2] Nottingham Univ Hosp NHS Trust, Dept Clin Haematol, Nottingham, England

[3] United Lincolnshire Hosp NHS Trust, Dept Haematol, Lincoln, England

[4] Christie Hosp NHS Trust, Dept Haematol, Manchester, Lancs, England

[5] Milton Keynes Dist Gen Hosp, Dept Haematol, Milton Keynes, Bucks, England

[6] Birmingham Heartlands Hosp, Dept Haematol & Stem Cell Transplantat, Birmingham, W Midlands, England

[7] Rotherham NHS Fdn Trust, Dept Clin Haematol, Rotherham, S Yorkshire, England

[8] Univ Oxford, John Radcliffe Hosp, NIHR BRC Oxford Mol Diagnost Ctr, Oxford Univ Hosp NHS Trust, Oxford, England

[9] Univ Oxford, John Radcliffe Hosp, Dept Oncol, Oxford, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2019年 / 184卷 / 04期

关键词：

idelalisib; TP53; deletion; B-PLL; prolymphocytic leukaemia; PROLYMPHOCYTIC LEUKEMIA;

D O I：

10.1111/bjh.15151

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：667 / 671

页数：5

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