Optimal preoperative neoadjuvant therapy for resectable locally advanced esophageal squamous cell carcinoma

被引:79
作者
Leng, Xue-Feng [1 ]
Daiko, Hiroyuki [2 ]
Han, Yong-Tao [1 ]
Mao, You-Sheng [3 ]
机构
[1] Univ Elect Sci & Technol China UESTC, Sichuan Canc Hosp & Res Inst, Sch Med, Div Thorac Surg, 55,Sect 4,South Renmin Rd, Chengdu 610041, Peoples R China
[2] Natl Canc Ctr, Dept Esophageal Surg, Tokyo, Japan
[3] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Thorac Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China
关键词
esophageal squamous cell carcinoma; multidisciplinary treatment; neoadjuvant chemoradiotherapy; neoadjuvant chemotherapy; neoadjuvant immunotherapy; LYMPH-NODE DISSECTION; PHASE-III TRIAL; MINIMALLY INVASIVE ESOPHAGECTOMY; PATHOLOGICAL COMPLETE RESPONSE; PERIOPERATIVE CHEMOTHERAPY; EXPERT CONSENSUS; OPEN-LABEL; CANCER; CHEMORADIOTHERAPY; SURVIVAL;
D O I
10.1111/nyas.14508
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide, especially in East Asia. ESCC accounts for more than 90% of esophageal cancer. Currently, neoadjuvant therapy in combination with surgical resection is the mainstay of treatment. However, the overall survival rate of patients with locally advanced ESCC is not satisfactory even when treated following the standard treatment guidelines. With neoadjuvant chemoradiotherapy, chemotherapy, or emerging immunotherapy, continuous exploration of efficacy in relation to ESCC is expected to improve overall survival further. Here, we review and summarize current evidence for efficacy of preoperative therapy for locally advanced ESCC.
引用
收藏
页码:213 / 224
页数:12
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