European Multicentre Study in Children Born Small for Gestational Age with Persistent Short Stature: Comparison of Continuous and Discontinuous Growth Hormone Treatment Regimens

被引:10
作者
Phillip, Moshe [1 ,2 ]
Lebenthal, Yael [2 ]
Lebl, Jan [4 ]
Zuckerman-Levin, Nehama [3 ]
Korpal-Szczyrska, Maria [5 ]
Marques, Jorge Sales [6 ]
Steensberg, Adam [7 ]
Jons, Kirsten [7 ]
Kappelgaard, Anne-Marie [7 ]
Ibanez, Lourdes [8 ]
机构
[1] Tel Aviv Univ, Schneider Childrens Med Ctr Israel, Natl Ctr Childhood Diabet, Inst Endocrinol & Diabet, IL-69978 Tel Aviv, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[3] Meyer Childrens Hosp, Rambam Med Ctr, Haifa, Israel
[4] Charles Univ Prague, Fac Med 2, Dept Paediat, Prague, Czech Republic
[5] Med Univ Gdansk, Dept Pediat Endocrinol, Gdansk, Poland
[6] Ctr Hosp Vila Nova Gaia, Dept Pediat, Gaia, Portugal
[7] Novo Nordisk AS, Global Dev, Copenhagen, Denmark
[8] Univ Barcelona, Hosp St Joan de Deu, Endocrine Unit, Barcelona, Spain
关键词
Small for gestational age; Growth hormone; Short stature; CATCH-UP GROWTH; GH TREATMENT; DOUBLE-BLIND; LONG-TERM; TURNER-SYNDROME; ADULT HEIGHT; METABOLISM; RESISTANCE; RESPONSES; THERAPY;
D O I
10.1159/000173742
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The most effective growth hormone (GH)treatment regimen for increasing height in short children born small for gestational age (SGA) has not been well defined. Methods: Short SGA children (n=151, age 3-8 years, height less than -2.5 standard deviation scores) were randomised to receive low-dose GH for 2 years (0.033/0.033 mg/kg/day, n=51), high-dose GH for 1 year and then no treatment for 1 year (0.100/0 mg/kg/day, n=51) or were untreated for 1 year then received mid-dose GH for 1 year (0/0.067 mg/kg/day, n=47). Height, bone age and adverse events were determined at check-ups every 3 months. Results: The mean +/- SD additional height gain with GH after 1 year, relative to untreated controls, was higher with discontinuous high-dose than with continuous low-dose GH (6.5 +/- 0.2 vs. 3.3 +/- 0.2 cm). After 2 years, the additional height gain was similar between high- and low-dose GH groups (between-group treatment difference=0.2, 95% CI=-0.8 to 1.2 cm, p=0.702). Patients treated exclusively in the last year had a similar height gain to those in the other treatment groups (p=0.604). Conclusions: In short SGA children, continuous low-dose and discontinuous high- dose GH regimens were associated with similar height gain. Treatment with mid-dose GH for 1 year also led to a similar improvement in growth. Copyright (C) 2008 S. Karger AG, Basel
引用
收藏
页码:52 / 59
页数:8
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