Association between retinol binding protein 4 with atherosclerotic markers in obese children

被引：1
作者：
Santanam, Nalini [1 ]
Elitsur, Yoram [2 ]
Stanek, Ronald [3 ]
Hotiana, Mateen [3 ]
Wheaton, Jennifer [3 ]
Kheetan, Reem [3 ]
Aljayoussi, Randa [3 ]
Gress, Todd [3 ]
Yaqub, Abid [3 ]
机构：
[1] Marshall Univ, Joan C Edwards Sch Med, Dept Pharmacol Physiol & Toxicol, One John Marshall Dr, Huntington, WV 25755 USA
[2] Marshall Univ, Joan C Edwards Sch Med, Dept Pediat, Sect Pediat Gastroenterol, Huntington, WV USA
[3] Marshall Univ, Joan C Edwards Sch Med, Dept Internal Med, Endocrinol Sect, Huntington, WV 25755 USA
来源：
MINERVA ENDOCRINOLOGICA | 2016年 / 41卷 / 03期
关键词：
Atherosclerosis; Biernarkers; Pediatric obesity; Inflammation; LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME COMPONENTS; CIRCULATING OXIDIZED LDL; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; ADIPOSE-TISSUE; SERUM RETINOL; RISK-FACTOR; RETINOL-BINDING-PROTEIN-4;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BACKGROUND: Childhood obesity increases cardiovascular tiskqluring adulthood.Retinol-lbinding protein-4, a pro-inflammatory adipokine, associated with obesity and'insUlin.resistatiee also plays a role in atherogenesis in adults. The goal of this study was to identify the relation between RBP4 and atherogenic markers in obse children. METHODS: In a cross-sectional study, obese add non-obese children (8-18 years) were prospectively recruited from a pediatric Appalachian population. Clinical markets such as lipid profile HbAIc, markers of insulin resistance and plasma levels of RBP4, sVCAM-1 and oxidized low-density lipoprotein(Ox-LDL) were measured. RESULTS: Compared to non-obese children RBP4 (P=0.016) and Ox-LDLA (P<0.001) were significantly higher in obese children and were positively correlated wiih-Body Mass/Index (P<0.001), BMI-SDS (Standard-Deviation Score) (P<0.001) and waist eircumference:(P=0.03). CONCLUSIONS: No significant correlation was found between inflammatory markers and Homeostatic Model Assessment -2, HDL, triglycerides, and HbAIc in obese children.
引用
收藏
页码：291 / 297
页数：7
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