Do Transferrin Levels Predict Haemodialysis Adequacy in Patients with End-Stage Renal Disease?

被引:7
作者
Tarantino, Giovanni [1 ]
Vinciguerra, Mauro [2 ]
Ragosta, Annalisa [3 ]
Citro, Vincenzo [4 ]
Conforti, Paolo [5 ]
Salvati, Giovanni [3 ]
Sorrentino, Aniello [6 ]
Barretta, Luca [6 ]
Balsano, Clara [7 ]
Capone, Domenico [8 ]
机构
[1] Univ Naples Federico II, Med Sch Naples, Dept Clin Med & Surg, I-80131 Naples, Italy
[2] Santa Maria Delle Grazie Hosp, Nephrol Sect, I-80078 Pozzuoli, Italy
[3] Dial Ctr Srl, Outpatients Clin Hemohaemodialysis, I-80038 Naples, Italy
[4] Umberto I Hosp, Dept Gen Med, I-84014 Salerno, Italy
[5] Univ Naples Federico II, Med Sch Naples, I-80131 Naples, Italy
[6] Diagnost Ctr Kappa Srl, I-80038 Naples, Italy
[7] Univ Aquila, Dept Clin Med Life Hlth & Environm Sci MESVA, I-67100 Laquila, Italy
[8] Univ Naples Federico II, Sect Med Pharmacol & Toxicol, Integrated Care Dept Publ Hlth & Drug Use, I-80131 Naples, Italy
关键词
nutritional status; inflammation; iron status; haemodialysis adequacy; NUTRITIONAL RISK INDEX; DIALYSIS PATIENTS; MORTALITY; IRON; MALNUTRITION; INFLAMMATION; FAILURE; KT/V; HEPCIDIN;
D O I
10.3390/nu11051123
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Since haemodialysis is a lifesaving therapy, adequate control measures are necessary to evaluate its adequacy and to constantly adjust the dose to reduce hospitalisation and prolong patient survival. Malnutrition is common in haemodialysis patients and closely related to morbidity and mortality. Patients undergoing haemodialysis have a high prevalence of protein-energy malnutrition and inflammation, along with abnormal iron status. The haemodialysis dose delivered is an important predictor of patient outcome. Aim: To evaluate through haemodialysis adequacy, which parameter(s), if any, better predict Kt/V, among those used to assess nutritional status, inflammation response, and iron status. Methods: We retrospectively studied 78 patients undergoing haemodialysis due to end-stage renal disease. As parameters of nutritional status, geriatric nutritional risk index (GNRI), transferrin levels, lymphocyte count, and albumin concentration were analysed. As signs of inflammation, C reactive protein (CRP) levels and ferritin concentrations were studied as well. Iron status was evaluated by both transferrin and ferritin levels, as well as by haemoglobin (Hb) concentration. Results: The core finding of our retrospective study is that transferrin levels predict the adequacy of haemodialysis expressed as Kt/V; the latter is the only predictor (P = 0.001) when adjusting for CRP concentrations, a solid marker of inflammation, and for ferritin levels considered an iron-storage protein, but also a parameter of inflammatory response. Discussion and Conclusion: In keeping with the results of this study, we underline that the use of transferrin levels to assess haemodialysis quality combine into a single test the evaluation of the three most important factors of protein-energy wasting.
引用
收藏
页数:11
相关论文
共 30 条
  • [1] [Anonymous], 2001, Am J Kidney Dis, V37, pS7
  • [2] [Anonymous], 1929, KLIN WOCHENSCHR, DOI DOI 10.1007/BF01738018
  • [3] Kt/V urea does not tell it all
    Basile, Carlo
    Lomonte, Carlo
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2012, 27 (04) : 1284 - 1287
  • [4] Daugirdas JT, 2015, AM J KIDNEY DIS, V66, P884, DOI 10.1053/j.ajkd.2015.07.015
  • [5] DAUGIRDAS JT, 1993, J AM SOC NEPHROL, V4, P1205
  • [6] Geriatric Nutritional Risk Index: A Mortality Predictor in Hemodialysis Patients
    Edalat-Nejad, Mahnaz
    Zameni, Fatemeh
    Qlich-Khani, Mahdi
    Salehi, Fatemeh
    [J]. SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION, 2015, 26 (02) : 302 - 308
  • [7] A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease
    Fouque, D.
    Kalantar-Zadeh, K.
    Kopple, J.
    Cano, N.
    Chauveau, P.
    Cuppari, L.
    Franch, H.
    Guarnieri, G.
    Ikizler, T. A.
    Kaysen, G.
    Lindholm, B.
    Massy, Z.
    Mitch, W.
    Pineda, E.
    Stenvinkel, P.
    Trevinho-Becerra, A.
    Wanner, C.
    [J]. KIDNEY INTERNATIONAL, 2008, 73 (04) : 391 - 398
  • [8] MALNUTRITION IN HEMODIALYSIS-PATIENTS
    HAKIM, RM
    LEVIN, N
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1993, 21 (02) : 125 - 137
  • [9] MORTALITY AND DURATION OF HEMODIALYSIS-TREATMENT
    HELD, PJ
    LEVIN, NW
    BOVBJERG, RR
    PAULY, MV
    DIAMOND, LH
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 265 (07): : 871 - 875
  • [10] Acute-phase proteins: As diagnostic tool
    Jain, Sachin
    Gautam, Vidhi
    Naseem, Sania
    [J]. JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2011, 3 (01): : 118 - 127