Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant

被引：459

作者：

Persaud, Deborah ^{[1
]}

Gay, Hannah ^{[4
]}

Ziemniak, Carrie ^{[1
]}

Chen, Ya Hui ^{[1
]}

Piatak, Michael, Jr. ^{[2
]}

Chun, Tae-Wook ^{[3
]}

Strain, Matthew ^{[5
,6
]}

Richman, Douglas ^{[5
,6
]}

Luzuriaga, Katherine ^{[7
,8
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21287 USA

[2] Leidos Biomed Res, Frederick Natl Lab Canc Res, Frederick, MD USA

[3] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[4] Univ Mississippi, Dept Pediat, Med Ctr, Jackson, MS USA

[5] Univ Calif San Diego, La Jolla, CA 92093 USA

[6] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA

[7] Univ Massachusetts, Sch Med, Dept Pediat, Program Mol Med, Worcester, MA USA

[8] Univ Massachusetts, Sch Med, Ctr Clin & Translat Sci, Worcester, MA USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2013年 / 369卷 / 19期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; EFFECTIVE ANTIRETROVIRAL THERAPY; INFECTED INFANTS; DYNAMICS; CHILDREN; TRANSMISSION; REPLICATION; CLEARANCE; TIME; RESERVOIRS;

D O I：

10.1056/NEJMoa1302976

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.

引用

页码：1828 / 1835

页数：8

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