Efficient synthesis of tetrahydronaphthalene- or isochroman-fused spirooxindoles using tandem reactions

被引：23

作者：

Wang, Biao ^{[1
]}

Leng, Hai-Jun ^{[2
]}

Yang, Xue-Yuan ^{[1
]}

Han, Bo ^{[1
]}

Rao, Chao-Long ^{[2
]}

Liu, Li ^{[2
]}

Peng, Cheng ^{[1
,2
]}

Huang, Wei ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Sch Pharm, Minist Educ, Key Lab Standardizat Chinese Med, Chengdu 611137, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 107期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; ASYMMETRIC-SYNTHESIS; CASCADE REACTIONS; NATURAL-PRODUCTS; DRUG-LIKE; DERIVATIVES; CYCLIZATION; MICHAEL; SCAFFOLDS; OXINDOLES;

D O I：

10.1039/c5ra15735h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The flexible and simple cascade reaction involving a Michael-aldol or vinylogous Henry-acetalization relay is described. We have used the cascade reaction to assemble functionalized tetrahydronaphthalene- or isochroman-fused spirooxindoles and other drug-like spirocyclic scaffolds. The mild reaction conditions, short reaction times, and high tolerance for various functional groups make this method attractive for constructing pharmacologically interesting architectures.

引用

页码：88272 / 88276

页数：5

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