机构:
Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USAScripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
Han, Xuemei
[1
]
Aslanian, Aaron
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机构:
Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USAScripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
Aslanian, Aaron
[1
,2
]
Yates, John R., III
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机构:
Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USAScripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
Yates, John R., III
[1
]
机构:
[1] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
[2] Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA
Mass spectrometry has been widely used to analyze biological samples and has evolved into an indispensable tool for proteomics research. Our desire to understand the proteome has led to new technologies that push the boundary of mass spectrometry capabilities, which in return has allowed mass spectrometry to address an ever-increasing array of biological questions. The recent development of a novel mass spectrometer (Orbitrap) and new dissociation methods such as electron-transfer dissociation has made possible the exciting new areas of proteomic application. Although bottom-up proteomics (analysis of proteolytic peptide mixtures) remains the workhorse for proteomic analysis, middle-down and topdown strategies (analysis of longer peptides and intact proteins, respectively) should allow more complete characterization of protein isoforms and post-translational modifications. Finally, stable isotope labeling strategies have transformed mass spectrometry from merely descriptive to a tool for measuring dynamic changes in protein expression, interaction, and modification.
机构:
Univ Wisconsin, Dept Chem, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Phanstiel, Doug
Brumbaugh, Justin
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h-index: 0
机构:
Univ Wisconsin, Integrated Program Biochem, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Brumbaugh, Justin
Berggren, W. Travis
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h-index: 0
机构:
WiCell Res Inst, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Berggren, W. Travis
Conard, Kevin
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机构:
WiCell Res Inst, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Conard, Kevin
Feng, Xuezhu
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h-index: 0
机构:
Univ Wisconsin, Dept Anat, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Feng, Xuezhu
Levenstein, Mark E.
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WiCell Res Inst, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Levenstein, Mark E.
McAlister, Graeme C.
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h-index: 0
机构:
Univ Wisconsin, Dept Chem, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
McAlister, Graeme C.
Thomson, James A.
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机构:
Univ Wisconsin, Dept Anat, Madison, WI 53706 USA
Univ Wisconsin, Genome Ctr Wisconsin, Madison, WI 53706 USA
Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53706 USA
WiCell Res Inst, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Thomson, James A.
Coon, Joshua J.
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h-index: 0
机构:
Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
Univ Wisconsin, Dept Biomol Chem, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
机构:SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
Shi, SDH
Hemling, ME
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h-index: 0
机构:
SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USASmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
Hemling, ME
Carr, SA
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h-index: 0
机构:SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
Carr, SA
Horn, DM
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h-index: 0
机构:SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
Horn, DM
Lindh, I
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机构:SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
Lindh, I
McLafferty, FW
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h-index: 0
机构:SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
机构:
Univ Wisconsin, Dept Chem, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Phanstiel, Doug
Brumbaugh, Justin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Integrated Program Biochem, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Brumbaugh, Justin
Berggren, W. Travis
论文数: 0引用数: 0
h-index: 0
机构:
WiCell Res Inst, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Berggren, W. Travis
Conard, Kevin
论文数: 0引用数: 0
h-index: 0
机构:
WiCell Res Inst, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Conard, Kevin
Feng, Xuezhu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Anat, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Feng, Xuezhu
Levenstein, Mark E.
论文数: 0引用数: 0
h-index: 0
机构:
WiCell Res Inst, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Levenstein, Mark E.
McAlister, Graeme C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Chem, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
McAlister, Graeme C.
Thomson, James A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Anat, Madison, WI 53706 USA
Univ Wisconsin, Genome Ctr Wisconsin, Madison, WI 53706 USA
Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53706 USA
WiCell Res Inst, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
Thomson, James A.
Coon, Joshua J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
Univ Wisconsin, Dept Biomol Chem, Madison, WI 53706 USAUniv Wisconsin, Dept Chem, Madison, WI 53706 USA
机构:SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
Shi, SDH
Hemling, ME
论文数: 0引用数: 0
h-index: 0
机构:
SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USASmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
Hemling, ME
Carr, SA
论文数: 0引用数: 0
h-index: 0
机构:SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
Carr, SA
Horn, DM
论文数: 0引用数: 0
h-index: 0
机构:SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
Horn, DM
Lindh, I
论文数: 0引用数: 0
h-index: 0
机构:SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA
Lindh, I
McLafferty, FW
论文数: 0引用数: 0
h-index: 0
机构:SmithKline Beecham Pharmaceut PLC, Dept Phys & Struct Chem, King Of Prussia, PA 19406 USA