Optical microangiography provides correlation between microstructure and microvasculature of optic nerve head in human subjects

被引：30
作者：
An, Lin [1 ]
Johnstone, Murray [2 ]
Wang, Ruikang K. [1 ,2 ]
机构：
[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA
[2] Univ Washington, Dept Ophthalmol, Seattle, WA 98104 USA
来源：
JOURNAL OF BIOMEDICAL OPTICS | 2012年 / 17卷 / 11期
基金：
美国国家卫生研究院;
关键词：
optical microangiography; optical coherence tomography; tissue morphology; functional microcirculation; optic nerve head; lamina cribrosa; OPEN-ANGLE GLAUCOMA; OCULAR BLOOD-FLOW; INTRAOCULAR-PRESSURE; COHERENCE TOMOGRAPHY; PERFUSION-PRESSURE; HUMAN SKIN; INTACT; MICE;
D O I：
10.1117/1.JBO.17.11.116018
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
It is demonstrated that optical microangiography (OMAG) is capable of imaging the detailed microstructure and microvasculature of the in vivo human optic nerve head (ONH), including the prelaminar tissue, the lamina cribrosa, the scleral rim and the vessels in the region of the circle of Zin-Haller. For demonstration, an ultrahigh sensitive OMAG system operating in the 850 nm wavelength region and a 500 kHz A-scan rate resulting in a spatial resolution of similar to 6 mu m were used. It was shown that OMAG provides superior results for three-dimensional imaging of the ONH compared to conventional optical coherence tomography by simultaneously recording both the microstructure and the functional microcirculation. The blood supply to the tissues of the ONH is an essential physiologic parameter needed for clinical assessment of the health of the nerve. (c) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI:10.1117/1.JBO.17.11.116018]
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页数：6
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