Expression of chromogranin/secretogranin mRNA in spontaneous mammary tumors in aging Fischer-344 rats

被引：2
作者：
Umemura, S [1 ]
Iwasaka, T [1 ]
Osamura, RY [1 ]
机构：
[1] Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa 2591193, Japan
来源：
PATHOLOGY INTERNATIONAL | 2001年 / 51卷 / 09期
关键词：
chromogranin; mammary tumor; neuroendocrine differentiation; reverse transcription-polymerase chain reaction; (RT-PCR); secretogranin;
D O I：
10.1046/j.1440-1827.2001.01267.x
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
There is a type of human breast cancer showing a neuroendocrine differentiation. Little is known, however, about the cell origin of this cancer or the process by which it expresses neuroendocrine features. Rat mammary tumors, either spontaneous or induced, have not been subjects for the investigation of aspects regarding the neuroendocrine differentiation of mammary epithelial cells. The aim of the present study was to show the potential of rat mammary tumors for expressing chromogranin (Cg)/secretogranin (Sg) mRNA. We examined CgA, SgI and SgII mRNA expression by reverse transcription-polymerase chain reaction in rat mammary adenocarcinoma and fibroadenoma which had arisen spontaneously in aging Fischer-344 rats. CgA and SgII mRNA were expressed in both mammary tumors, but SgI mRNA was not detected in either. The results of the present study show that rat mammary tumors can express chromogranin genes.
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页码：667 / 670
页数：4
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