Childhood Linear IgA Bullous Disease Triggered by Amoxicillin-Clavulanic Acid

被引:39
作者
Ho, Jean Chin Ching [1 ]
Ng, Pei Lin Patricia [1 ]
Tan, Suat Hoon [1 ]
Giam, Yoke Chin [1 ]
机构
[1] Natl Skin Ctr, Singapore 308205, Singapore
关键词
D O I
10.1111/j.1525-1470.2007.00438.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Linear immunoglobulin A bullous disease is an autoimmune subepidermal blistering disease that has been described in both children and adults. Reports have shown that as many as two-thirds of occurrences may be drug-induced. The offending drugs include antibiotics, predominantly vancomycin, nonsteroidal anti-inflammatory agents and diuretics. We report childhood linear immunoglobulin A bullous dermatosis developing following amoxicillin-clavulanic acid administration. The patient presented with characteristic blisters in an annular fashion, likened to a "crown of jewels." The diagnosis was confirmed by the presence of a linear band of immunoglobulin A at the dermoepidermal junction on direct immunofluorescence. The lesions resolved with withdrawal of the drug, and systemic therapy was not required. We review the current literature and concepts of drug-induced linear immunoglobulin A bullous disease.
引用
收藏
页码:E40 / E43
页数:4
相关论文
共 32 条
[1]   Phenytoin-induced linear IgA bullous disease [J].
Acostamadiedo, JM ;
Perniciaro, C ;
Rogers, RS .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1998, 38 (02) :352-356
[2]   Linear IgA disease: the IgA and IgG response to the epidermal antigens demonstrates that intermolecular epitope spreading is associated with IgA rather than IgG antibodies, and is more common in adults [J].
Allen, J ;
Wojnarowska, F .
BRITISH JOURNAL OF DERMATOLOGY, 2003, 149 (05) :977-985
[3]   Acetaminophen-induced linear IgA bullous dermatosis [J].
Avci, O ;
Ökmen, M ;
Çetiner, S .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 48 (02) :299-301
[4]   VANCOMYCIN-INDUCED LINEAR IGA BULLOUS DERMATOSIS [J].
BADEN, LA ;
APOVIAN, C ;
IMBER, MJ ;
DOVER, JS .
ARCHIVES OF DERMATOLOGY, 1988, 124 (08) :1186-1188
[5]   Naproxen-associated linear IgA bullous dermatosis: Case report and review [J].
Bouldin, MB ;
Clowers-Webb, HE ;
Davis, JL ;
McEvoy, MT ;
Davis, MDP .
MAYO CLINIC PROCEEDINGS, 2000, 75 (09) :967-970
[6]   Drug-induced linear IgA bullous dermatosis probably induced by furosemide [J].
Cerottini, JP ;
Ricci, C ;
Guggisberg, D ;
Panizzon, RG .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1999, 41 (01) :103-105
[7]   Vancomycin-associated linear IgA bullous dermatosis mimicking toxic epidermal necrolysis [J].
Dellavalle, RP ;
Burch, JM ;
Tayal, S ;
Golitz, LE ;
Fitzpatrick, JE ;
Walsh, P .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 48 (05) :S56-S57
[8]  
Dmochowski Marian, 1993, Journal of Dermatological Science, V6, P194
[9]   Linear IgA disease with IgA antibodies directed against 200-and 280-kDa epidermal antigens [J].
Fujimoto, W ;
Ohtsu, T ;
Toi, Y ;
Nakanishi, G ;
Arata, J .
BRITISH JOURNAL OF DERMATOLOGY, 2000, 142 (06) :1213-1218
[10]   LINEAR IGA BULLOUS DERMATOSIS ASSOCIATED WITH RHEUMATOID-ARTHRITIS [J].
HAYAKAWA, K ;
SHIOHARA, T ;
YAGITA, A ;
NAGASHIMA, M .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1992, 26 (01) :110-113