Decreased serum level of IL-21 in new-onset systemic lupus erythematosus patients

被引：24

作者：

Pan, Hai-Feng ^{[1
,2
]}

Wu, Guo-Cui ^{[3
]}

Fan, Yin-Guang ^{[1
,2
]}

Leng, Rui-Xue ^{[1
,2
]}

Peng, Hui ^{[1
,2
]}

Zhou, Mo ^{[1
,2
]}

Li, Bao-Zhu ^{[1
,2
]}

Zhu, Yan ^{[1
,2
]}

Tao, Jin-Hui ^{[4
]}

Li, Xiang-Pei ^{[4
]}

Ye, Dong-Qing ^{[1
,2
]}

机构：

[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China

[2] Anhui Med Univ, Anhui Prov Lab Populat Hlth & Major Dis Screening, Hefei 230032, Anhui, Peoples R China

[3] First Peoples Hosp, Dept Pharmacol, Hefei 230001, Anhui, Peoples R China

[4] Anhui Prov Hosp, Dept Rheumatol, Hefei, Peoples R China

来源：

RHEUMATOLOGY INTERNATIONAL | 2013年 / 33卷 / 09期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

IL-21; Th17; Systemic lupus erythematosus; Lupus nephritis; T-CELL; INTERLEUKIN-21; DISEASE; ASSOCIATION; RECEPTOR; REGION; GENE; POLYMORPHISM; VARIANTS; RISK;

D O I：

10.1007/s00296-013-2724-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study aims to investigate the serum IL-21 levels in systemic lupus erythematosus (SLE) and its relations with clinical and laboratory features. Fifty-seven patients with SLE and 30 healthy volunteers were recruited in the current study. Serum IL-21 levels were detected by enzyme-linked immunosorbent assay. Statistical analyses were performed by SPSS 10.01. Results showed that IL-21 levels were significantly decreased in the serum of patients with SLE compared with controls (P = 0.026). There was no significant difference regarding serum IL-21 level between SLE patients with nephritis and those without nephritis (P = 0.066); no significant difference was found between less active SLE and more active SLE (P = 0.588). The presence of anemia was associated with low serum IL-21 levels (P = 0.030) in SLE patients. In summary, decreased serum level of IL-21 and its association with anemia indicate a possible role of IL-21 in human SLE. However, further studies are needed to confirm this preliminary results.

引用

页码：2337 / 2342

页数：6

共 31 条

[21] Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study [J].

Teixeira, Vitor Hugo ;

Pierlot, Celine ;

Migliorini, Paola ;

Balsa, Alejandro ;

Westhovens, Rene ;

Barrera, Pilar ;

Alves, Helena ;

Vaz, Carlos ;

Fernandes, Manuela ;

Pascual-Salcedo, Dora ;

Bombardieri, Stefano ;

Dequeker, Jan ;

Radstake, Timothy R. ;

Van Riel, Piet ;

van de Putte, Leo ;

Lopes-Vaz, Antonio ;

Bardin, Thomas ;

Prum, Bernard ;

Cornelis, Francois ;

Petit-Teixeira, Elisabeth .

ARTHRITIS RESEARCH & THERAPY, 2009, 11 (02)

[22] Interleukin 21 Correlates with T Cell and B Cell Subset Alterations in Systemic Lupus Erythematosus [J].

Terrier, Benjamin ;

Costedoat-Chalumeau, Nathalie ;

Garrido, Marlene ;

Geri, Guillaume ;

Rosenzwajg, Michelle ;

Musset, Lucile ;

Klatzmann, David ;

Saadoun, David ;

Cacoub, Patrice .

JOURNAL OF RHEUMATOLOGY, 2012, 39 (09) :1819-1828

[23] A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 [J].

van Heel, David A. ;

Franke, Lude ;

Hunt, Karen A. ;

Gwilliam, Rhian ;

Zhernakova, Alexandra ;

Inouye, Mike ;

Wapenaar, Martin C. ;

Barnardo, Martin C. N. M. ;

Bethel, Graeme ;

Holmes, Geoffrey K. T. ;

Feighery, Con ;

Jewell, Derek ;

Kelleher, Dermot ;

Kumar, Parveen ;

Travis, Simon ;

Walters, Julian R. F. ;

Sanders, David S. ;

Howdle, Peter ;

Swift, Jill ;

Playford, Raymond J. ;

McLaren, William M. ;

Mearin, M. Luisa ;

Mulder, Chris J. ;

McManus, Ross ;

McGinnis, Ralph ;

Cardon, Lon R. ;

Deloukas, Panos ;

Wijmenga, Cisca .

NATURE GENETICS, 2007, 39 (07) :827-829

[24] IL-21 Promotes Lupus-like Disease in Chronic Graft-versus-Host Disease through Both CD4 T Cell- and B Cell-Intrinsic Mechanisms [J].

Vinh Nguyen ;

Luzina, Irina ;

Rus, Horea ;

Tegla, Cosmin ;

Chen, Ching ;

Rus, Violeta .

JOURNAL OF IMMUNOLOGY, 2012, 189 (02) :1081-1093

[25] A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity [J].

Vinuesa, CG ;

Cook, MC ;

Angelucci, C ;

Athanasopoulos, V ;

Rui, LX ;

Hill, KM ;

Yu, D ;

Domaschenz, H ;

Whittle, B ;

Lambe, T ;

Roberts, IS ;

Copley, RR ;

Bell, JI ;

Cornall, RJ ;

Goodnow, CC .

NATURE, 2005, 435 (7041) :452-458

[26] SYSTEMIC LUPUS-ERYTHEMATOSUS IN GREECE - CLINICAL-FEATURES, EVOLUTION AND OUTCOME - A DESCRIPTIVE ANALYSIS OF 292 PATIENTS [J].

VLACHOYIANNOPOULOS, PG ;

KARASSA, FB ;

KARAKOSTAS, KX ;

DROSOS, AA ;

MOUTSOPOULOS, HM .

LUPUS, 1993, 2 (05) :303-312

[27] Anaemia in systemic lupus erythematosus: aetiological profile and the role of erythropoietin [J].

Voulgarelis, M ;

Kokori, SIG ;

Ioannidis, JPA ;

Tzioufas, AG ;

Kyriaki, D ;

Moutsopoulos, HM .

ANNALS OF THE RHEUMATIC DISEASES, 2000, 59 (03) :217-222

[28] A Polymorphism Within IL21R Confers Risk for Systemic Lupus Erythematosus [J].

Webb, Ryan ;

Merrill, Joan T. ;

Kelly, Jennifer A. ;

Sestak, Andrea ;

Kaufman, Kenneth M. ;

Langefeld, Carl D. ;

Ziegler, Julie ;

Kimberly, Robert P. ;

Edberg, Jeffrey C. ;

Ramsey-Goldman, Rosalind ;

Petri, Michelle ;

Reveille, John D. ;

Alarcon, Graciela S. ;

Vila, Luis M. ;

Alarcon-Riquelme, Marta E. ;

James, Judith A. ;

Gilkeson, Gary S. ;

Jacob, Chaim O. ;

Moser, Kathy L. ;

Gaffney, Patrick M. ;

Vyse, Timothy J. ;

Nath, Swapan K. ;

Lipsky, Peter ;

Harley, John B. ;

Sawalha, Amr H. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (08) :2402-2407

[29] Elevated Production of B Cell Chemokine CXCL13 is Correlated with Systemic Lupus Erythematosus Disease Activity [J].

Wong, C. K. ;

Wong, Purple T. Y. ;

Tam, L. S. ;

Li, Edmund K. ;

Chen, D. P. ;

Lam, Christopher W. K. .

JOURNAL OF CLINICAL IMMUNOLOGY, 2010, 30 (01) :45-52

[30] Copy Number Variations of Interleukin-17F, Interleukin-21, and Interleukin-22 Are Associated With Systemic Lupus Erythematosus [J].

Yu, Bo ;

Guan, Ming ;

Peng, Yinghui ;

Shao, Yong ;

Zhang, Chao ;

Yue, Xupeng ;

Zhang, Jie ;

Yang, Hong ;

Zou, Hejian ;

Ye, Wencai ;

Wan, Jun ;

Zhang, Wei .

ARTHRITIS AND RHEUMATISM, 2011, 63 (11) :3487-3492

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