Sarcopenia and sarcopenic obesity

被引:229
作者
Choi, Kyung Mook [1 ]
机构
[1] Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, 73 Inchon Ro, Seoul 02841, South Korea
基金
新加坡国家研究基金会;
关键词
Sarcopenia; Obesity; Aging; Muscles; SKELETAL-MUSCLE MASS; LOWER-EXTREMITY FUNCTION; METABOLIC SYNDROME; BODY-COMPOSITION; OLDER-ADULTS; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; MORTALITY; ASSOCIATION; HEALTH;
D O I
10.3904/kjim.2016.193
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sarcopenia is an age-associated loss of muscle mass and decline in muscle strength; it is common in older adults and is associated with significant morbidity and mortality. Despite its prevalence, there is currently no universally adopted definition of sarcopenia. In addition to low muscle mass measurements, recent research has recognized the importance of muscle strength and physical performance. Aging induces changes in body composition, such as an increase in visceral fat and reduced muscle mass. Recently, the new concept of sarcopenic obesity has emerged, reflecting a combination of sarcopenia and obesity. The rapidly increasing prevalence and serious consequences of sarcopenic obesity are recognized as a critical public health risk in the aging society. Sarcopenia and obesity share several pathophysiological mechanisms, and they may potentiate each other. The present paper reviews the definitions and techniques used to measure sarcopenia, as well as the health outcomes of sarcopenic obesity. It also highlights the role of diminished muscle mass and strength in cardiometabolic disease mortality. Additional research may be needed to promote the identification and management of sarcopenia and sarcopenic obesity in the elderly population.
引用
收藏
页码:1054 / 1060
页数:7
相关论文
共 63 条
[1]   DISCOVERING PATHWAYS OF SARCOPENIA IN OLDER ADULTS: A ROLE FOR INSULIN RESISTANCE ON MITOCHONDRIA DYSFUNCTION [J].
Abbatecola, A. M. ;
Paolisso, G. ;
Fattoretti, P. ;
Evans, W. J. ;
Fiore, V. ;
Dicioccio, L. ;
Lattanzio, F. .
JOURNAL OF NUTRITION HEALTH & AGING, 2011, 15 (10) :890-895
[2]   Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: A Population-Based Cohort Study of Older Men [J].
Atkins, Janice L. ;
Whincup, Peter H. ;
Morris, Richard W. ;
Lennon, Lucy T. ;
Papacosta, Olia ;
Wannamethee, S. Goya .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2014, 62 (02) :253-260
[3]   Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III [J].
Batsis, J. A. ;
Mackenzie, T. A. ;
Barre, L. K. ;
Lopez-Jimenez, F. ;
Bartels, S. J. .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2014, 68 (09) :1001-1007
[4]   Epidemiology of sarcopenia among the elderly in New Mexico [J].
Baumgartner, RN ;
Koehler, KM ;
Gallagher, D ;
Romero, L ;
Heymsfield, SB ;
Ross, RR ;
Garry, PJ ;
Lindeman, RD .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1998, 147 (08) :755-763
[5]  
Baumgartner RN, 2000, ANN NY ACAD SCI, V904, P437
[6]   Diagnostic criteria for sarcopenia relate differently to insulin resistance [J].
Bijlsma, A. Y. ;
Meskers, C. G. M. ;
van Heemst, D. ;
Westendorp, R. G. J. ;
de Craen, A. J. M. ;
Maier, A. B. .
AGE, 2013, 35 (06) :2367-2375
[7]  
Cawthon PM, 2013, GERONTOLOGIST, V53, P594, DOI 10.1093/gerona/glu023
[8]   Sarcopenia and Sarcopenic Obesity [J].
Choi, Kyung Mook .
ENDOCRINOLOGY AND METABOLISM, 2013, 28 (02) :86-89
[9]   Body composition and its association with cardiometabolic risk factors in the elderly: A focus on sarcopenic obesity [J].
Chung, Ji-Youn ;
Kang, Hee-Taik ;
Lee, Duk-Chul ;
Lee, Hye-Ree ;
Lee, Yong-Jae .
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2013, 56 (01) :270-278
[10]   Sarcopenia: European consensus on definition and diagnosis [J].
Cruz-Jentoft, Alfonso J. ;
Baeyens, Jean Pierre ;
Bauer, Juergen M. ;
Boirie, Yves ;
Cederholm, Tommy ;
Landi, Francesco ;
Martin, Finbarr C. ;
Michel, Jean-Pierre ;
Rolland, Yves ;
Schneider, Stephane M. ;
Topinkova, Eva ;
Vandewoude, Maurits ;
Zamboni, Mauro .
AGE AND AGEING, 2010, 39 (04) :412-423