Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules

被引：114

作者：

Oehninger, Luciano ^{[1
]}

Stefanopoulou, Maria ^{[2
]}

Alborzinia, Hamed ^{[3
]}

Schur, Julia ^{[1
]}

Ludewig, Stephanie ^{[1
]}

Namikawa, Kazuhiko ^{[4
]}

Munoz-Castro, Alvaro ^{[5
]}

Koester, Reinhard W. ^{[4
]}

Baumann, Knut ^{[1
]}

Woelfl, Stefan ^{[3
]}

Sheldrick, William S. ^{[2
]}

Ott, Ingo ^{[1
]}

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, D-38106 Braunschweig, Germany

[2] Ruhr Univ Bochum, Lehrstuhl Analyt Chem, D-44780 Bochum, Germany

[3] Heidelberg Univ, Inst Pharm & Mol Biotechnol, D-69120 Heidelberg, Germany

[4] Tech Univ Carolo Wilhelmina Braunschweig, Inst Zool, Div Cell Biol & Cell Physiol, D-38106 Braunschweig, Germany

[5] Univ Andres Bello, Dept Chem Sci, Santiago 275, Chile

来源：

DALTON TRANSACTIONS | 2013年 / 42卷 / 05期

关键词：

THIOREDOXIN REDUCTASE; ANTICANCER ACTIVITY; GOLD(I) COMPLEXES; IN-VITRO; BINDING; INHIBITION; ACTIVATION; CELLS;

D O I：

10.1039/c2dt32319b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Metal complexes with N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry and are now increasingly considered for the development of new chemical tools and metal based drugs. Ruthenium complexes of the type (p-cymene)(NHC)RuCl2 interacted with biologically relevant thiols and selenols, which resulted in the inhibition of enzymes such as thioredoxin reductase or cathepsin B. Pronounced antiproliferative effects could be obtained provided that an appropriate cellular uptake was achieved. Inhibition of tumor cell growth was accompanied by a perturbation of metabolic parameters such as cellular respiration.

引用

页码：1657 / 1666

页数：10

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