The outer membrane fraction of Flavobacterium psychrophilum induces protective immunity in rainbow trout and ayu

被引：62
作者：
Rahman, MH [1 ]
Kuroda, A
Dijkstra, JM
Kiryu, I
Nakanishi, T
Ototake, M
机构：
[1] Natl Res Inst Aquaculture, Fisheries Res Agcy, Immunol Sect, Tamaki, Mie 5190423, Japan
[2] Nihon Univ, Dept Vet Med, Lab Fish Pathol, Kanagawa 2528570, Japan
来源：
FISH & SHELLFISH IMMUNOLOGY | 2002年 / 12卷 / 02期
关键词：
outer membrane; Flavobacterium psychrophilum; protective immunity; antibody titre; coldwater disease; rainbow trout; ayu; Plecoglossus altivelis;
D O I：
10.1006/fsim.2001.0362
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
Flavobacterium psychrophilum is the causative agent of coldwater disease, which is responsible for serious losses in fish aquaculture in several parts of the world. No commercial vaccines are currently available for the prevention of coldwater disease. The present study sought to assess the efficacy of a F. psychrophilum vaccine based on the antigenic outer membrane fraction (OMF). This fraction induced significantly higher protection against coldwater disease in both rainbow trout (Oncorhynchus mykiss) and ayu (Plecoglossus altivelis) compared to inactivated whole cell F. psychrophilum bacterin. Coincident with higher protection, sera of fish immunised with the OMF vaccine had higher agglutination titres than those of fish immunised with inactivated whole cell F. psychrophilum. (C) 2002 Academic Press.
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页码：169 / 179
页数：11
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